Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 3/20 | 0.52 |
| ▸ | AXL | P30530 | 1/20 | 0.52 |
| ▸ | AKT2 | P31751 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 7/20 | 0.48 |
| ▸ | JAK3 | P52333 | 7/20 | 0.48 |
| ▸ | JAK1 | P23458 | 6/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | CHUK | O15111 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PAK4 | O96013 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2279760 | 0.91 | JAK3 (0.55) | PRKCIAXLAKT2JAK2JAK3 | |
| SCHEMBL12605434 | 0.90 | ROCK1 (0.56) | PRKCIAXLAKT2JAK2JAK3 | |
| SCHEMBL12605431 | 0.89 | CHEK1 (0.46) | PRKCIAXLAKT2JAK2JAK3 | |
| SCHEMBL1723773 | 0.82 | PRKCI (0.42) | PRKCIAXLAKT2JAK2JAK3 | |
| SCHEMBL4063065 | 0.81 | JAK2 (0.56) | PRKCIAXLAKT2JAK2JAK3 | |
| SCHEMBL30009345 | 0.81 | JAK1 (0.60) | JAK2JAK3JAK1IKBKBCHUK | |
| SCHEMBL21821940 | 0.80 | PRKCI (0.44) | PRKCIAXLAKT2JAK2JAK3 | |
| SCHEMBL1724113 | 0.79 | PRKCI (0.46) | PRKCIAXLAKT2JAK2JAK3 | |
| SCHEMBL1752752 | 0.77 | PRKCI (0.47) | PRKCIAXLAKT2JAK2JAK3 | |
| SCHEMBL1723803 | 0.77 | PRKCI (0.44) | PRKCIAXLAKT2JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9617267-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2017-04-11 | — | — | US | disclosed |
| EP-2501236-B1 | N-[2-fluoro-3-(4-amino-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-phenyl]-4-benzenesulfonamide derivatives as Raf protein kinase modulators for the treatment of cancer | PLEXXIKON INC (US) | 2017-03-29 | — | — | EP | disclosed |
| CN-105906631-A | Compounds and methods for kinase modulation, and indications therefor | 普莱希科公司 | 2016-08-31 | — | — | CN | disclosed |
| US-20140288070-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. | 2014-09-25 | — | — | US | disclosed |
| US-8673928-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2014-03-18 | — | — | US | disclosed |
| CN-102740698-A | Compounds and methods for kinase modulation and indications therefor | PLEXXIKON INC | 2012-10-17 | — | — | CN | disclosed |
| US-20110152258-A1 | Compounds and Methods for Kinase Modulation, and Indications Therefor | PLEXXIKON INC. | 2011-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110152258-A1 | Compounds and Methods for Kinase Modulation, and Indications Therefor | BRAF, KRAS, RAF1 | PRKCI 151/4885AXL 364/4885AKT2 146/4885 |
| US-20140288070-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | BRAF, KRAS, RAF1 | PRKCI 151/4885AXL 364/4885AKT2 146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.