Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 8/20 | 0.68 |
| ▸ | JAK3 | P52333 | 7/20 | 0.68 |
| ▸ | JAK2 | O60674 | 11/20 | 0.48 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19823051 | 0.85 | JAK1 (0.77) | JAK1JAK3JAK2NUDT1PTK2 | |
| SCHEMBL21044832 | 0.82 | JAK1 (0.83) | JAK1JAK3JAK2NUDT1PTK2 | |
| SCHEMBL24062739 | 0.82 | JAK1 (0.70) | JAK1JAK3JAK2NUDT1PTK2 | |
| SCHEMBL21044840 | 0.81 | JAK1 (1.00) | JAK1JAK3JAK2PTK2 | |
| SCHEMBL24062632 | 0.81 | JAK1 (0.53) | JAK1JAK3JAK2PTK2 | |
| SCHEMBL19823062 | 0.80 | JAK1 (0.75) | JAK1JAK3JAK2PTK2 | |
| SCHEMBL24062643 | 0.80 | JAK1 (0.75) | JAK1JAK3JAK2PTK2 | |
| SCHEMBL21078412 | 0.80 | JAK1 (0.68) | JAK1JAK3JAK2NUDT1PTK2 | |
| SCHEMBL21078410 | 0.79 | JAK1 (0.64) | JAK1JAK3JAK2NUDT1PTK2 | |
| SCHEMBL2634468 | 0.71 | JAK2 (0.73) | JAK1JAK3JAK2NUDT1PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3492469-B1 | COMPOUND AS SELECTIVE JAK INHIBITOR, AND SALT AND THERAPEUTIC USE THEREOF | SUZHOU LONGBIOTECH PHARMACEUTICALS CO LTD (CN) | 2021-12-01 | — | — | EP | disclosed |
| EP-3492469-A1 | COMPOUND AS SELECTIVE JAK INHIBITOR, AND SALT AND THERAPEUTIC USE THEREOF | Tianjin Longbogene Pharmaceutical Co., Ltd. (CN) | 2019-06-05 | — | — | EP | disclosed |
| WO-2018019223-A1 | COMPOUND AS SELECTIVE JAK INHIBITOR, AND SALT AND THERAPEUTIC USE THEREOF | 张文燕 | 2018-02-01 | — | — | WO | disclosed |