Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA2 | Q15349 | 17/20 | 0.45 |
| ▸ | RPS6KA3 | P51812 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16101756 | 0.81 | POLB (0.37) | RPS6KA2POLBKDM4EALDH1A1HPGD | |
| SCHEMBL1985895 | 0.76 | RPS6KA2 (0.65) | RPS6KA2RPS6KA3 | |
| SCHEMBL1993378 | 0.71 | RPS6KA2 (0.64) | RPS6KA2RPS6KA3 | |
| SCHEMBL1979447 | 0.70 | RPS6KA2 (0.41) | RPS6KA2RPS6KA3POLB | |
| SCHEMBL16095959 | 0.70 | HRH3 (0.46) | RPS6KA2RPS6KA3 | |
| SCHEMBL14904455 | 0.69 | RPS6KA2 (0.58) | RPS6KA2RPS6KA3 | |
| SCHEMBL1978769 | 0.67 | RPS6KA2 (0.61) | RPS6KA2RPS6KA3 | |
| SCHEMBL1982424 | 0.67 | RPS6KA2 (0.64) | RPS6KA2RPS6KA3 | |
| SCHEMBL3083411 | 0.66 | RPS6KA3 (0.52) | RPS6KA2RPS6KA3ALDH1A1HPGD | |
| SCHEMBL1979617 | 0.65 | RPS6KA3 (0.48) | RPS6KA2RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509980-A1 | HETEROCYCLIC COMPOUNDS CONTAINING AN INDOLE CORE | Boehringer Ingelheim International GmbH (DE) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011071716-A1 | HETEROCYCLIC COMPOUNDS CONTAINING AN INDOLE CORE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-06-16 | — | — | WO | disclosed |