Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA2 | Q15349 | 12/20 | 0.55 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.52 |
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1979144 | 0.73 | RPS6KA2 (1.00) | RPS6KA2RPS6KA3 | |
| SCHEMBL1979007 | 0.73 | RPS6KA2 (0.60) | RPS6KA2RPS6KA3MAPKAPK2 | |
| SCHEMBL1979968 | 0.72 | RPS6KA2 (1.00) | RPS6KA2RPS6KA3MAPKAPK2 | |
| SCHEMBL3079464 | 0.70 | RPS6KA3 (1.00) | RPS6KA2RPS6KA3MAPKAPK2 | |
| SCHEMBL7396812 | 0.69 | RPS6KA3 (0.43) | RPS6KA2RPS6KA3ADRA2A | |
| SCHEMBL15249223 | 0.68 | CDK2 (0.53) | RPS6KA2RPS6KA3CCNE1CDK2 | |
| SCHEMBL30172384 | 0.67 | RPS6KA3 (0.53) | RPS6KA2RPS6KA3MAPKAPK2 | |
| SCHEMBL1393632 | 0.67 | RPS6KA3 (0.53) | RPS6KA2RPS6KA3MAPKAPK2 | |
| SCHEMBL1979881 | 0.67 | RPS6KA2 (0.59) | RPS6KA2RPS6KA3 | |
| SCHEMBL31300701 | 0.67 | RPS6KA2 (0.59) | RPS6KA2RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011071716-A1 | HETEROCYCLIC COMPOUNDS CONTAINING AN INDOLE CORE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-06-16 | — | — | WO | disclosed |