Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 16/20 | 0.39 |
| ▸ | NTRK3 | Q16288 | 8/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 6/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19827028 | 0.92 | NTRK1 (0.39) | NTRK1NTRK3NTRK2JAK2TGFBR1 | |
| SCHEMBL16947092 | 0.88 | NTRK1 (0.46) | NTRK1NTRK3NTRK2JAK2 | |
| SCHEMBL19826848 | 0.87 | NTRK1 (0.40) | NTRK1JAK2TGFBR1ADORA3ADORA2A | |
| SCHEMBL19826993 | 0.87 | NTRK1 (0.36) | NTRK1NTRK3NTRK2JAK2TGFBR1 | |
| SCHEMBL19827083 | 0.85 | NTRK1 (0.41) | NTRK1NTRK3NTRK2TGFBR1 | |
| SCHEMBL29422688 | 0.82 | NTRK1 (0.39) | NTRK1NTRK3NTRK2JAK2TGFBR1 | |
| SCHEMBL21081097 | 0.82 | NTRK1 (0.47) | NTRK1NTRK3NTRK2TGFBR1 | |
| SCHEMBL22688715 | 0.81 | NTRK1 (0.40) | NTRK1NTRK3NTRK2JAK2ADORA3 | |
| SCHEMBL22688714 | 0.81 | NTRK1 (0.40) | NTRK1NTRK3NTRK2JAK2ADORA3 | |
| SCHEMBL19827027 | 0.80 | NTRK1 (0.40) | NTRK1JAK2TGFBR1ADORA3ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018022911-A1 | MACROCYCLE KINASE INHIBITORS | TP THERAPEUTICS, INC. (US) | 2018-02-01 | — | — | WO | disclosed |