Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBFB | Q13951 | 6/20 | 0.70 |
| ▸ | RUNX1 | Q01196 | 11/20 | 0.59 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19831268 | 1.00 | CBFB (0.70) | CBFBRUNX1TRPV1DGAT1PDE10A | |
| SCHEMBL179114 | 1.00 | CBFB (0.70) | CBFBRUNX1TRPV1DGAT1PDE10A | |
| SCHEMBL126350 | 0.94 | CBFB (0.66) | CBFBRUNX1TRPV1DGAT1 | |
| SCHEMBL179106 | 0.91 | CBFB (0.84) | CBFBRUNX1TRPV1DGAT1 | |
| SCHEMBL29377925 | 0.91 | CBFB (0.84) | CBFBRUNX1TRPV1DGAT1PDE10A | |
| SCHEMBL24245908 | 0.90 | CBFB (0.69) | CBFBRUNX1TRPV1DGAT1 | |
| SCHEMBL19831437 | 0.88 | CBFB (0.56) | CBFBRUNX1TRPV1DGAT1 | |
| SCHEMBL24950162 | 0.87 | CBFB (0.65) | CBFBRUNX1TRPV1DGAT1 | |
| SCHEMBL19831265 | 0.87 | CBFB (0.65) | CBFBRUNX1TRPV1DGAT1 | |
| SCHEMBL19831262 | 0.86 | CBFB (0.56) | CBFBRUNX1TRPV1DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11241421-B2 | Combination therapies for treating cancer | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2022-02-08 | — | — | US | disclosed |
| US-20210205280-A1 | COMBINATION THERAPIES FOR TREATING CANCER | UNIVERSITY OF MASSACHUSETTS | 2021-07-08 | — | — | US | disclosed |
| US-20190343820-A1 | COMBINATION THERAPIES FOR TREATING CANCER | UNIVERSITY OF VIRGINIA | 2019-11-14 | — | — | US | disclosed |
| WO-2018022855-A1 | COMBINATION THERAPIES FOR TREATING CANCER | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2018-02-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190343820-A1 | COMBINATION THERAPIES FOR TREATING CANCER | MCL1, MLLT1, FLI1 | CBFB 334/4885RUNX1 17/4885TRPV1 4863/4885 |
| US-11241421-B2 | Combination therapies for treating cancer | MCL1, MLLT1, FLI1 | CBFB 334/4885RUNX1 17/4885TRPV1 4863/4885 |
| US-20210205280-A1 | COMBINATION THERAPIES FOR TREATING CANCER | BRD4, BET1, FLI1 | CBFB 71/4885RUNX1 32/4885TRPV1 3440/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.