Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.85 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.85 |
| ▸ | POLB | P06746 | 5/20 | 0.85 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.85 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.85 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.85 |
| ▸ | BLM | P54132 | 1/20 | 0.85 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.85 |
| ▸ | TP53 | P04637 | 5/20 | 0.76 |
| ▸ | MAPT | P10636 | 4/20 | 0.68 |
| ▸ | LMNA | P02545 | 3/20 | 0.68 |
| ▸ | GLA | P06280 | 1/20 | 0.68 |
| ▸ | PKM | P14618 | 1/20 | 0.68 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.68 |
| ▸ | KLK7 | P49862 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 2/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16024106 | 0.92 | MEN1 (0.91) | MEN1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL1962693 | 0.90 | TP53 (0.76) | MEN1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL1962692 | 0.90 | TP53 (0.76) | MEN1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL17489619 | 0.89 | MEN1 (0.85) | MEN1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL17487046 | 0.89 | MEN1 (0.85) | MEN1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL16024136 | 0.88 | MEN1 (0.83) | MEN1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL17489632 | 0.87 | MEN1 (0.66) | MEN1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL17489620 | 0.86 | MEN1 (0.80) | MEN1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL16024108 | 0.86 | MEN1 (0.80) | MEN1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL16024079 | 0.85 | MEN1 (0.80) | MEN1KMT2APOLBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964618-B1 | QUINAZOLINONE ANTIBIOTICS | UNIV NOTRE DAME DU LAC (US) | 2019-09-04 | — | — | EP | disclosed |
| US-20180029997-A1 | QUINAZOLINONE ANTIBIOTICS | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2018-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180029997-A1 | QUINAZOLINONE ANTIBIOTICS | Q6ZSR9, TOP2A, CEP170 | MEN1 4776/4885KMT2A 2228/4885POLB 176/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.