Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.33 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19085085 | 0.84 | CCR1 (0.39) | KCNH2BRD4NPSR1CYP1A2HRH4 | |
| SCHEMBL25885363 | 0.82 | PARP1 (0.36) | KCNH2PARP1BRD4NPSR1CYP1A2 | |
| SCHEMBL13793158 | 0.80 | KDM4E (0.46) | CYP1A2 | |
| SCHEMBL12432224 | 0.80 | IRAK4 (0.49) | KCNH2PARP1BRD4NPSR1CYP1A2 | |
| SCHEMBL22931529 | 0.78 | IRAK4 (0.41) | KCNH2PARP1BRD4NPSR1CYP1A2 | |
| SCHEMBL15102639 | 0.76 | GRIN2D (0.44) | KCNH2PARP1BRD4CYP1A2IRAK4 | |
| SCHEMBL979568 | 0.76 | KDM4E (0.61) | PARP1BRD4CYP1A2 | |
| SCHEMBL45869 | 0.75 | KCNH2 (0.52) | KCNH2PARP1NPSR1HRH4GRIN2D | |
| Hydrochloric Acid SCHEMBL5239638 | 0.74 | KDM4E (0.59) | PARP1BRD4CYP1A2 | |
| SCHEMBL2829475 | 0.74 | PARP1 (0.54) | KCNH2PARP1BRD4NPSR1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021155321-A2 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2021-08-05 | — | — | WO | disclosed |
| WO-2020198537-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS | ESCIENT PHARMACEUTICALS, INC. (US) | 2020-10-01 | — | — | WO | disclosed |
| EP-3300500-B1 | TRIAZOLE AGONISTS OF THE APJ RECEPTOR | AMGEN INC (US) | 2020-02-26 | — | — | EP | disclosed |
| EP-2944633-B1 | PYRIDINE DERIVATIVE | TEIJIN PHARMA LTD (JP) | 2018-01-31 | — | — | EP | disclosed |