Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 16/20 | 0.64 |
| ▸ | NR1H3 | Q13133 | 16/20 | 0.64 |
| ▸ | PPARA | Q07869 | 10/20 | 0.54 |
| ▸ | PPARD | Q03181 | 10/20 | 0.54 |
| ▸ | PPARG | P37231 | 10/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6099787 | 0.91 | NR1H2 (0.66) | NR1H2NR1H3PPARAPPARDPPARG | |
| SCHEMBL6098261 | 0.88 | NR1H2 (0.66) | NR1H2NR1H3PPARAPPARDPPARG | |
| SCHEMBL6102420 | 0.86 | NR1H2 (0.46) | NR1H2NR1H3PPARAPPARDPPARG | |
| SCHEMBL6100866 | 0.85 | NR1H2 (0.78) | NR1H2NR1H3PPARAPPARDPPARG | |
| SCHEMBL6099203 | 0.85 | NR1H3 (0.67) | NR1H2NR1H3PPARAPPARDPPARG | |
| SCHEMBL6102250 | 0.84 | NR1H3 (0.66) | NR1H2NR1H3PPARAPPARDPPARG | |
| SCHEMBL6100211 | 0.84 | NR1H2 (0.76) | NR1H2NR1H3PPARAPPARDPPARG | |
| SCHEMBL6099405 | 0.83 | NR1H2 (0.65) | NR1H2NR1H3PPARAPPARDPPARG | |
| SCHEMBL6100273 | 0.82 | NR1H2 (0.76) | NR1H2NR1H3PPARAPPARDPPARG | |
| SCHEMBL6100036 | 0.82 | NR1H2 (0.73) | NR1H2NR1H3PPARAPPARDPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10583102-B2 | Targeting liver nuclear receptors as a treatment for wilson disease | THE JOHNS HOPKINS UNIVERSITY (US) | 2020-03-10 | — | — | US | disclosed |
| US-20180036264-A1 | TARGETING LIVER NUCLEAR RECEPTORS AS A TREATMENT FOR WILSON DISEASE | THE JOHNS HOPKINS UNIVERSITY | 2018-02-08 | — | — | US | disclosed |