Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR2 | O60603 | 19/20 | 0.86 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.53 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19839697 | 1.00 | TLR2 (0.86) | TLR2SIRT6SIRT1 | |
| SCHEMBL19839598 | 1.00 | TLR2 (0.86) | TLR2SIRT6SIRT1 | |
| SCHEMBL19839587 | 0.92 | TLR2 (1.00) | TLR2SIRT6SIRT1 | |
| SCHEMBL19839589 | 0.92 | TLR2 (1.00) | TLR2SIRT6SIRT1 | |
| Hydrochloric Acid SCHEMBL19839887 | 0.91 | TLR2 (1.00) | TLR2SIRT6SIRT1 | |
| Hydrochloric Acid SCHEMBL19839885 | 0.91 | TLR2 (1.00) | TLR2SIRT6SIRT1 | |
| SCHEMBL19839573 | 0.89 | TLR2 (0.69) | TLR2SIRT6SIRT1 | |
| SCHEMBL19839553 | 0.89 | TLR2 (0.69) | TLR2SIRT6SIRT1 | |
| SCHEMBL19839555 | 0.89 | TLR2 (0.69) | TLR2SIRT6SIRT1 | |
| SCHEMBL19839711 | 0.85 | TLR2 (0.64) | TLR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3493814-A1 | LIPID-SUBSTITUTED AMINO 1,2-AND 1,3-DIOL COMPOUNDS AS MODULATORS OF TLR2 DIMERIZATION | Neuropore Therapies, Inc. (US) | 2019-06-12 | — | — | EP | claimed |
| WO-2018026866-A1 | LIPID-SUBSTITUTED AMINO 1,2-AND 1,3-DIOL COMPOUNDS AS MODULATORS OF TLR2 DIMERIZATION | NEUROPORE THERAPIES, INC. (US) | 2018-02-08 | — | — | WO | claimed |