Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 9/20 | 0.60 |
| ▸ | EMG1 | Q92979 | 2/20 | 0.60 |
| ▸ | MME | P08473 | 18/20 | 0.48 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24022288 | 1.00 | ACE (0.60) | ACEEMG1MMEMMEL1 | |
| SCHEMBL17011362 | 1.00 | ACE (0.60) | ACEEMG1MMEMMEL1 | |
| SCHEMBL17011168 | 0.90 | ACE (0.62) | ACEEMG1MMEMMEL1 | |
| SCHEMBL23420472 | 0.90 | ACE (0.62) | ACEEMG1MMEMMEL1 | |
| SCHEMBL17011164 | 0.90 | ACE (0.65) | ACEEMG1MMEMMEL1 | |
| SCHEMBL17011167 | 0.88 | ACE (0.77) | ACEEMG1MME | |
| SCHEMBL19825614 | 0.88 | ACE (0.77) | ACEEMG1MME | |
| SCHEMBL19825615 | 0.88 | ACE (0.77) | ACEEMG1MME | |
| SCHEMBL17011159 | 0.88 | ACE (0.77) | ACEEMG1MMEMMEL1 | |
| SCHEMBL9930001 | 0.88 | ACE (0.64) | ACEEMG1MMEMMEL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9884807-B2 | Neprilysin inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2018-02-06 | — | — | US | disclosed |