Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13572999 | 1.00 | GRM1 (0.52) | GRM1KDM4ERAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL19844773 | 1.00 | GRM1 (0.52) | GRM1KDM4ERAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL23875675 | 0.90 | GRM1 (0.51) | GRM1KDM4EALDH1A1PLD1MAPT | |
| SCHEMBL8091809 | 0.90 | GRM1 (0.51) | GRM1KDM4EALDH1A1PLD1MAPT | |
| SCHEMBL23875353 | 0.83 | PLD1 (0.52) | GRM1KDM4EALDH1A1PLD1MAPT | |
| SCHEMBL29505439 | 0.81 | GRM1 (0.49) | GRM1KDM4EALDH1A1KAT2BPLD1 | |
| SCHEMBL723065 | 0.81 | PRKCQ (0.53) | GRM1KDM4EKAT2BMAP4K4PLD1 | |
| SCHEMBL29683665 | 0.81 | PRKCQ (0.53) | GRM1KDM4EKAT2BMAP4K4PLD1 | |
| SCHEMBL27981822 | 0.81 | PLD1 (0.47) | GRM1KDM4EALDH1A1KAT2BPLD1 | |
| SCHEMBL13035335 | 0.80 | KDM4E (0.53) | GRM1KDM4EALDH1A1KAT2BPLD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180037566-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2018-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180037566-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | HDAC10, HDAC6, HDAC11 | GRM1 1593/4885KDM4E 1434/4885RAB9A 1575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.