Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 11/20 | 0.72 |
| ▸ | LCK | P06239 | 7/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.53 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.53 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.53 |
| ▸ | JAK2 | O60674 | 2/20 | 0.53 |
| ▸ | ABL1 | P00519 | 2/20 | 0.53 |
| ▸ | INSR | P06213 | 2/20 | 0.53 |
| ▸ | FYN | P06241 | 2/20 | 0.53 |
| ▸ | YES1 | P07947 | 2/20 | 0.53 |
| ▸ | LYN | P07948 | 2/20 | 0.53 |
| ▸ | RET | P07949 | 2/20 | 0.53 |
| ▸ | MET | P08581 | 2/20 | 0.53 |
| ▸ | ROS1 | P08922 | 2/20 | 0.53 |
| ▸ | KIT | P10721 | 2/20 | 0.53 |
| ▸ | SRC | P12931 | 2/20 | 0.53 |
| ▸ | BRAF | P15056 | 2/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.53 |
| ▸ | FLT1 | P17948 | 2/20 | 0.53 |
| ▸ | TYK2 | P29597 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22087495 | 0.84 | LCK (0.71) | FGFR3LCKCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL374547 | 0.84 | FGFR3 (1.00) | FGFR3LCKFGFR1FGFR2FGFR4 | |
| SCHEMBL22132803 | 0.84 | FGFR3 (0.72) | FGFR3LCKFGFR1FGFR2FGFR4 | |
| SCHEMBL374521 | 0.80 | FGFR3 (0.81) | FGFR3LCKFGFR1FGFR2FGFR4 | |
| SCHEMBL374049 | 0.79 | FGFR3 (1.00) | FGFR3LCKFGFR1FGFR2FGFR4 | |
| SCHEMBL583166 | 0.78 | FGFR3 (0.86) | FGFR3LCKFGFR1FGFR2FGFR4 | |
| SCHEMBL374211 | 0.76 | FGFR3 (0.87) | FGFR3LCKFGFR1FGFR2FGFR4 | |
| SCHEMBL374643 | 0.75 | FGFR3 (0.72) | FGFR3LCKFGFR1FGFR2FGFR4 | |
| SCHEMBL374757 | 0.75 | FGFR3 (0.80) | FGFR3LCKFGFR1FGFR2FGFR4 | |
| SCHEMBL374413 | 0.74 | FGFR3 (0.81) | FGFR3LCKFGFR1FGFR2FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2790718-B1 | ANTAGONIST OF THE FIBROBLAST GROWTH FACTOR RECEPTOR 3 (FGFR3) FOR USE IN THE TREATMENT OR THE PREVENTION OF SKELETAL DISORDERS LINKED WITH ABNORMAL ACTIVATION OF FGFR3 | INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECH MÉDICALE (INSERM) (FR) | 2018-02-07 | — | — | EP | disclosed |