⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1829564 | 0.92 | — | — | |
| SCHEMBL5368830 | 0.85 | — | — | |
| SCHEMBL1435624 | 0.79 | — | — | |
| SCHEMBL8190601 | 0.74 | — | — | |
| SCHEMBL728127 | 0.72 | — | — | |
| SCHEMBL728126 | 0.72 | — | — | |
| SCHEMBL12671786 | 0.72 | — | — | |
| SCHEMBL812832 | 0.72 | — | — | |
| SCHEMBL22721435 | 0.72 | — | — | |
| SCHEMBL13840787 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 112 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024022481-A1 | PHENYL-SUBSTITUTED DIHYDRONAPHTHYRIDINE COMPOUNDS, AND PREPARATION AND USE THEREOF | 苏中药业集团股份有限公司 | 2024-02-01 | — | — | WO | claimed |
| CN-113121393-A | Aromatic amide compound and application thereof in medicines | 广东东阳光药业有限公司 | 2021-07-16 | — | — | CN | claimed |
| US-20210206760-A1 | PHENYL-SUBSTITUTED DIHYDRONAPHTHYRIDINE COMPOUND AND USE THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2021-07-08 | — | — | US | claimed |
| EP-3798219-A1 | PHENYL-SUBSTITUTED DIHYDRONAPHTHYRIDINE COMPOUND AND USE THEREOF | Sunshine Lake Pharma Co., Ltd. (CN) | 2021-03-31 | — | — | EP | claimed |
| WO-2020239050-A1 | 2-(2-CHLORO-4-METHYLPHENYL)QUINAZOLINE-4(3H)-KETONE COMPOUND AND MEDICAL USE THEREOF | 中国人民解放军军事科学院军事医学研究院 | 2020-12-03 | — | — | WO | claimed |
| CN-110511219-A | The dihydronaphthridine class compound and application thereof that phenyl replaces | GUANGDONG HEC PHARMACEUTICAL | 2019-11-29 | — | — | CN | claimed |
| CN-110041273-A | 2- (the chloro- 4- aminomethyl phenyl of 2-) quinazoline -4 (3H) -one class compound and its medical usage | 中国人民解放军军事科学院军事医学研究院 | 2019-07-23 | — | — | CN | claimed |
| EP-2318363-A1 | HETEROCYCLIC DERIVATIVES AS IAP BINDING COMPOUNDS | Nuevolution A/S (DK) | 2011-05-11 | — | — | EP | claimed |
| CN-100577658-C | Quinazoline derivatives | ASTRAZENECA AB | 2010-01-06 | — | — | CN | claimed |
| WO-2009152824-A1 | HETEROCYCLIC DERIVATIVES AS IAP BINDING COMPOUNDS | NUEVOLUTION A/S (DK) | 2009-12-23 | — | — | WO | claimed |
| CN-1993349-A | Quinazoline derivatives as ERBB receptor tyrosine kinases | ASTRAZENECA AB (SE) | 2007-07-04 | — | — | CN | claimed |
| JP-2007506716-A | — | — | 2007-03-22 | — | — | JP | claimed |
| EP-1756088-A1 | QUINAZOLINE DERIVATIVES AS ERBB RECEPTOR TYROSINE KINASES | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | claimed |
| US-20070043010-A1 | Quinazoline derivatives | ASTRAZENECA UK LIMITED (GB) | 2007-02-22 | — | — | US | claimed |
| CN-1886399-A | Quinazoline derivatives | ASTRAZENECA AB (SE) | 2006-12-27 | — | — | CN | claimed |
| EP-1670786-A1 | QUINAZOLINE DERIVATIVES | Astrazeneca AB (SE) | 2006-06-21 | — | — | EP | claimed |
| WO-2005118572-A1 | QUINAZOLINE DERIVATIVES AS ERBB RECEPTOR TYROSINE KINASES | ASTRAZENECA AB (SE) | 2005-12-15 | — | — | WO | claimed |
| WO-2005030757-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-04-07 | — | — | WO | claimed |
| CN-1059336-A | Anti-fungal triazole derivatives and preparation thereof and purposes | SANKYO CO (JP) | 1992-03-11 | — | — | CN | claimed |
| EP-0473387-A2 | Anti-fungal triazole derivatives, their preparation and uses | Sankyo Company Limited (JP) | 1992-03-04 | — | — | EP | claimed |