Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28641490 | 1.00 | HTT (0.52) | HTTATMUSP2SMN1; SMN2ALDH1A1 | |
| SCHEMBL28641488 | 1.00 | HTT (0.52) | HTTATMUSP2SMN1; SMN2ALDH1A1 | |
| SCHEMBL17292388 | 0.89 | HTT (0.50) | HTTATMUSP2SMN1; SMN2ALDH1A1 | |
| SCHEMBL15533550 | 0.89 | HTT (0.50) | HTTATMUSP2SMN1; SMN2ALDH1A1 | |
| SCHEMBL3982522 | 0.85 | HTT (0.52) | HTTATMUSP2SMN1; SMN2ALDH1A1 | |
| SCHEMBL17708312 | 0.83 | HTT (0.54) | HTTATMUSP2SMN1; SMN2ALDH1A1 | |
| SCHEMBL3720687 | 0.83 | HTT (0.54) | HTTATMUSP2SMN1; SMN2ALDH1A1 | |
| SCHEMBL4546718 | 0.83 | HTT (0.54) | HTTATMUSP2SMN1; SMN2ALDH1A1 | |
| SCHEMBL1669097 | 0.81 | HTT (0.55) | HTTATMUSP2SMN1; SMN2ALDH1A1 | |
| SCHEMBL18294 | 0.78 | USP2 (0.69) | HTTATMUSP2SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3883647-A1 | C10-ALKYLENE SUBSTITUTED 13-MEMBERED MACROLIDES AND USES THEREOF | Zikani Therapeutics, Inc. (US) | 2021-09-29 | — | — | EP | disclosed |
| WO-2018026782-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | APTINYX INC. (US) | 2018-02-08 | — | — | WO | disclosed |