Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 18/20 | 0.74 |
| ▸ | TACR3 | P29371 | 2/20 | 0.74 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.74 |
| ▸ | FPR1 | P21462 | 1/20 | 0.74 |
| ▸ | GPR183 | P32249 | 1/20 | 0.74 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.74 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.74 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.74 |
| ▸ | TACR2 | P21452 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11929279 | 0.90 | TACR1 (0.80) | TACR1TACR3NR3C1CYP3A4FPR1 | |
| SCHEMBL18388496 | 0.89 | TACR1 (0.79) | TACR1TACR3NR3C1CYP3A4FPR1 | |
| Fosaprepitant SCHEMBL19749078 | 0.89 | TACR1 (0.73) | TACR1TACR3NR3C1CYP3A4FPR1 | |
| Fosaprepitant SCHEMBL21009635 | 0.89 | TACR1 (0.73) | TACR1TACR3NR3C1CYP3A4FPR1 | |
| Fosaprepitant SCHEMBL19749951 | 0.89 | TACR1 (0.73) | TACR1TACR3NR3C1CYP3A4FPR1 | |
| Fosaprepitant SCHEMBL12903477 | 0.89 | TACR1 (0.73) | TACR1TACR3NR3C1CYP3A4FPR1 | |
| Fosaprepitant SCHEMBL309491 | 0.89 | TACR1 (0.73) | TACR1TACR3NR3C1CYP3A4FPR1 | |
| SCHEMBL10281461 | 0.89 | TACR1 (0.78) | TACR1TACR3NR3C1CYP3A4FPR1 | |
| SCHEMBL18211935 | 0.89 | TACR1 (0.78) | TACR1TACR3NR3C1CYP3A4FPR1 | |
| SCHEMBL12534145 | 0.88 | TACR1 (0.72) | TACR1TACR3NR3C1CYP3A4FPR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4019023-A1 | FORMULATIONS OF FOSAPREPITANT AND APREPITANT | Zhuhai Beihai Biotech Co., Ltd. (CN) | 2022-06-29 | — | — | EP | disclosed |
| EP-3493815-B1 | FORMULATIONS OF FOSAPREPITANT AND APREPITANT | ZHUHAI BEIHAI BIOTECH CO LTD (CN) | 2022-02-16 | — | — | EP | disclosed |
| WO-2018027029-A1 | FORMULATIONS OF FOSAPREPITANT AND APREPITANT | ZHUHAI BEIHAI BIOTECH CO., LTD. (CN) | 2018-02-08 | — | — | WO | disclosed |