Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 20/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21573220 | 0.93 | BCL2 (0.82) | BCL2 | |
| SCHEMBL21573200 | 0.92 | BCL2 (0.69) | BCL2 | |
| SCHEMBL21573216 | 0.92 | BCL2 (0.73) | BCL2 | |
| SCHEMBL19853739 | 0.92 | BCL2 (0.76) | BCL2 | |
| SCHEMBL19853635 | 0.92 | BCL2 (0.72) | BCL2 | |
| SCHEMBL21573182 | 0.92 | BCL2 (0.69) | BCL2 | |
| SCHEMBL21573178 | 0.92 | BCL2 (0.69) | BCL2 | |
| SCHEMBL21573161 | 0.92 | BCL2 (0.75) | BCL2 | |
| SCHEMBL21573204 | 0.91 | BCL2 (0.76) | BCL2 | |
| SCHEMBL21573177 | 0.91 | BCL2 (0.76) | BCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023011488-A1 | PHARMACEUTICAL COMBINATION AND USE THEREOF | 苏州亚盛药业有限公司 | 2023-02-09 | — | — | WO | disclosed |
| WO-2022143602-A1 | METHODS OF TREATING MULTIPLE SCLEROSIS | ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) | 2022-07-07 | — | — | WO | disclosed |
| EP-3569601-B1 | N-(PHENYLSULFONYL)BENZAMIDES AND RELATED COMPOUNDS AS BCL-2 INHIBITORS | UNIV MICHIGAN REGENTS (US) | 2022-06-22 | — | — | EP | disclosed |
| EP-3672639-B1 | COMBINATION PRODUCT OF A BCL-2 INHIBITOR AND IBRUTINIB FOR USE IN THE PREVENTION AND/OR TREATMENT OF CANCER | ASCENTAGE PHARMA SUZHOU CO LTD (CN) | 2022-02-23 | — | — | EP | disclosed |
| WO-2021208911-A1 | NOVEL MEDICAL USE OF MDM2 INHIBITORS | ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) | 2021-10-21 | — | — | WO | disclosed |
| EP-3672594-B1 | COMBINATION PRODUCT OF BCL-2 INHIBITOR AND MDM2 INHIBITOR AND USE THEREOF IN THE PREVENTION AND/OR TREATMENT OF DISEASES | ASCENTAGE PHARMA SUZHOU CO LTD (CN) | 2021-09-29 | — | — | EP | disclosed |
| EP-3672595-B1 | COMBINATION PRODUCT OF BCL-2 INHIBITOR AND CHEMOTHERAPEUTIC AGENT AND USE THEREOF IN THE PREVENTION AND/OR TREATMENT OF DISEASES | ASCENTAGE PHARMA SUZHOU CO LTD (CN) | 2021-07-21 | — | — | EP | disclosed |
| WO-2021110097-A1 | N-(PHENYLSULFONYL)BENZAMIDES AND RELATED COMPOUNDS AS BCL-2 INHIBITORS | ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) | 2021-06-10 | — | — | WO | disclosed |
| WO-2021110136-A1 | PHARMACEUTICAL COMBINATION AND USE THEREOF | ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) | 2021-06-10 | — | — | WO | disclosed |
| WO-2021000899-A1 | A PHARMACEUTICAL COMBINATION CONTAINING mTOR INHIBITOR AND USE THEREOF | ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) | 2021-01-07 | — | — | WO | disclosed |
| EP-3494115-B1 | N-(PHENYLSULFONYL)BENZAMIDE DERIVATIVES AS BCL-2 INHIBITORS | UNIV MICHIGAN REGENTS (US) | 2020-10-21 | — | — | EP | disclosed |
| WO-2020024820-A1 | COMBINATION PRODUCT OF BCL-2 INHIBITOR AND MDM2 INHIBITOR AND USE THEREOF IN THE PREVENTION AND/OR TREATMENT OF DISEASES | ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) | 2020-02-06 | — | — | WO | disclosed |
| WO-2020024916-A1 | COMBINATION PRODUCT OF BCL-2 INHIBITOR OR BCL-2/BCL-XL DUAL INHIBITOR AND BTK INHIBITOR AND USE THEREOF IN THE PREVENTION AND/OR TREATMENT OF DISEASES | ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) | 2020-02-06 | — | — | WO | disclosed |
| WO-2020024826-A1 | SYNERGISTIC ANTITUMOR EFFECT OF BCL-2 INHIBITOR COMBINED WITH RITUXIMAB AND/OR BENDAMUSTINE OR BCL-2 INHIBITOR COMBINED WITH CHOP | ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) | 2020-02-06 | — | — | WO | disclosed |
| WO-2020024834-A1 | COMBINATION PRODUCT OF BCL-2 INHIBITOR AND CHEMOTHERAPEUTIC AGENT AND USE THEREOF IN THE PREVENTION AND/OR TREATMENT OF DISEASES | ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) | 2020-02-06 | — | — | WO | disclosed |
| EP-3569601-A2 | N-(PHENYLSULFONYL)BENZAMIDES AND RELATED COMPOUNDS AS BCL-2 INHIBITORS | The Regents of The University of Michigan (US) | 2019-11-20 | — | — | EP | disclosed |
| WO-2018027097-A1 | N-(PHENYLSULFONYL)BENZAMIDES AND RELATED COMPOUNDS AS BCL-2 INHIBITORS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2018-02-08 | — | — | WO | disclosed |