Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.36 |
| ▸ | STAT6 | P42226 | 1/20 | 0.36 |
| ▸ | CYP51A1 | Q16850 | 5/20 | 0.34 |
| ▸ | F2 | P00734 | 2/20 | 0.34 |
| ▸ | F9 | P00740 | 2/20 | 0.34 |
| ▸ | F10 | P00742 | 2/20 | 0.34 |
| ▸ | F12 | P00748 | 2/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.34 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.34 |
| ▸ | F7 | P08709 | 2/20 | 0.34 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.34 |
| ▸ | PYGL | P06737 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4335350 | 1.00 | TDP1 (0.36) | TDP1HTRA1STAT6CYP51A1F2 | |
| SCHEMBL19856915 | 1.00 | TDP1 (0.36) | TDP1HTRA1STAT6CYP51A1F2 | |
| SCHEMBL4343721 | 1.00 | TDP1 (0.36) | TDP1HTRA1STAT6CYP51A1F2 | |
| SCHEMBL4350449 | 0.95 | HTRA1 (0.36) | TDP1HTRA1STAT6CYP51A1F2 | |
| SCHEMBL4341332 | 0.95 | HTRA1 (0.36) | TDP1HTRA1STAT6CYP51A1F2 | |
| SCHEMBL4343831 | 0.91 | STAT6 (0.39) | HTRA1STAT6CYP51A1F2F10 | |
| SCHEMBL4338819 | 0.90 | STAT6 (0.40) | HTRA1STAT6CYP51A1PYGLKMT2A | |
| SCHEMBL19856939 | 0.89 | CYP51A1 (0.38) | HTRA1STAT6CYP51A1PYGLBCAT1 | |
| SCHEMBL19856944 | 0.89 | CYP51A1 (0.38) | HTRA1STAT6CYP51A1PYGLBCAT1 | |
| SCHEMBL8002978 | 0.87 | TDP1 (0.35) | TDP1HTRA1STAT6CYP51A1F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925857-B1 | USE OF TRPV4 ANTAGONISTS TO AMELIORATE HYDROCEPHALUS AND RELATED MATERIALS AND METHODS | UNIV INDIANA RES & TECH CORP (US) | 2018-02-14 | — | — | EP | claimed |