Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNKSR1 | Q969H4 | 4/20 | 0.65 |
| ▸ | AKT1 | P31749 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | BRAF | P15056 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | BCL2 | P10415 | 1/20 | 0.37 |
| ▸ | BID | P55957 | 1/20 | 0.37 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | BCL2L2 | Q92843 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15811556 | 1.00 | CNKSR1 (0.65) | CNKSR1AKT1ALDH1A1SMN1; SMN2BRAF | |
| SCHEMBL17213396 | 0.81 | CNKSR1 (0.65) | CNKSR1AKT1ALDH1A1SMN1; SMN2BRAF | |
| SCHEMBL19857081 | 0.80 | CNKSR1 (0.67) | CNKSR1AKT1ALDH1A1SMN1; SMN2BRAF | |
| SCHEMBL15811566 | 0.80 | CNKSR1 (0.67) | CNKSR1AKT1ALDH1A1SMN1; SMN2BRAF | |
| SCHEMBL15811539 | 0.80 | CNKSR1 (0.66) | CNKSR1AKT1ALDH1A1SMN1; SMN2BRAF | |
| SCHEMBL19857077 | 0.80 | CNKSR1 (0.66) | CNKSR1AKT1ALDH1A1SMN1; SMN2BRAF | |
| SCHEMBL19867224 | 0.80 | CNKSR1 (0.66) | CNKSR1AKT1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL15811527 | 0.79 | CNKSR1 (1.00) | CNKSR1AKT1ALDH1A1SMN1; SMN2BRAF | |
| SCHEMBL19857079 | 0.79 | CNKSR1 (0.65) | CNKSR1AKT1ALDH1A1SMN1; SMN2BRAF | |
| SCHEMBL17213426 | 0.79 | CNKSR1 (0.65) | CNKSR1AKT1ALDH1A1SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2931280-B1 | METHODS AND COMPOSITIONS FOR INHIBITING CNKSR1 | PHUSIS THERAPEUTICS INC (US) | 2018-02-14 | — | — | EP | disclosed |