Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIK1 | P57059 | 1/20 | 0.59 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.59 |
| ▸ | PAK1 | Q13153 | 7/20 | 0.47 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.47 |
| ▸ | MET | P08581 | 5/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19860023 | 0.93 | SIK1 (0.60) | SIK1SIK3PAK1PAK4TNIK | |
| SCHEMBL19860543 | 0.91 | SIK1 (0.59) | SIK1SIK3PAK1PAK4TNIK | |
| SCHEMBL15799513 | 0.90 | SIK1 (0.75) | SIK1SIK3PAK1PAK4TNIK | |
| SCHEMBL19860027 | 0.88 | SIK1 (0.65) | SIK1SIK3PAK1PAK4TNIK | |
| SCHEMBL15805420 | 0.87 | SIK1 (0.65) | SIK1SIK3PAK1PAK4TNIK | |
| SCHEMBL15799580 | 0.86 | SIK1 (0.72) | SIK1SIK3PAK1PAK4TNIK | |
| SCHEMBL16023064 | 0.85 | SIK1 (0.56) | SIK1SIK3PAK1PAK4TNIK | |
| SCHEMBL19860022 | 0.85 | SIK1 (0.79) | SIK1SIK3PAK1PAK4PDPK1 | |
| SCHEMBL15799340 | 0.82 | SIK1 (0.77) | SIK1SIK3PAK1PAK4TNIK | |
| SCHEMBL30830390 | 0.82 | SIK1 (0.77) | SIK1SIK3PAK1PAK4TNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890153-B2 | Substituted 1H-pyrrolo [2, 3-b] pyridine and 1H-pyrazolo [3, 4-b] pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors | ARRIEN PHARMACEUTICALS LLC (US) | 2018-02-13 | — | — | US | disclosed |