Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 16/20 | 0.60 |
| ▸ | LCK | P06239 | 8/20 | 0.60 |
| ▸ | KDR | P35968 | 8/20 | 0.60 |
| ▸ | INSR | P06213 | 7/20 | 0.60 |
| ▸ | LYN | P07948 | 6/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.60 |
| ▸ | FLT4 | P35916 | 5/20 | 0.60 |
| ▸ | FLT3 | P36888 | 5/20 | 0.60 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.60 |
| ▸ | CSF1R | P07333 | 4/20 | 0.60 |
| ▸ | KIT | P10721 | 4/20 | 0.60 |
| ▸ | FLT1 | P17948 | 4/20 | 0.60 |
| ▸ | MARK3 | P27448 | 4/20 | 0.60 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.60 |
| ▸ | BLK | P51451 | 4/20 | 0.60 |
| ▸ | NEK2 | P51955 | 4/20 | 0.60 |
| ▸ | LIMK1 | P53667 | 4/20 | 0.60 |
| ▸ | STK3 | Q13188 | 4/20 | 0.60 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3691085 | 0.93 | IGF1R (0.58) | IGF1RLCKKDRINSRLYN | |
| SCHEMBL1985864 | 0.93 | IGF1R (0.58) | IGF1RLCKKDRINSRLYN | |
| SCHEMBL1985865 | 0.93 | IGF1R (0.58) | IGF1RLCKKDRINSRLYN | |
| SCHEMBL6219133 | 0.90 | IGF1R (0.74) | IGF1RLCKKDRINSRLYN | |
| SCHEMBL1989235 | 0.89 | IGF1R (0.66) | IGF1RLCKKDRINSRLYN | |
| SCHEMBL1989237 | 0.89 | IGF1R (0.66) | IGF1RLCKKDRINSRLYN | |
| SCHEMBL3683012 | 0.89 | IGF1R (0.66) | IGF1RLCKKDRINSRLYN | |
| SCHEMBL1983640 | 0.88 | IGF1R (0.60) | IGF1RLCKKDRINSRLYN | |
| SCHEMBL1983642 | 0.88 | IGF1R (0.60) | IGF1RLCKKDRINSRLYN | |
| SCHEMBL1983068 | 0.85 | IGF1R (0.84) | IGF1RLCKKDRINSRLYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737493-B1 | INHIBITORS OF INSULIN-LIKE GROWTH FACTOR RECEPTOR -1 FOR INHIBITING TUMOR CELL GROWTH | DANA FARBER CANCER INST INC (US) | 2011-06-29 | — | — | EP | disclosed |