Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19015630 | 1.00 | EGFR (0.54) | EGFRERBB2 | |
| SCHEMBL19015241 | 0.92 | EGFR (0.60) | EGFRERBB2 | |
| SCHEMBL15749712 | 0.90 | EGFR (0.61) | EGFR | |
| SCHEMBL15749313 | 0.90 | EGFR (0.61) | EGFR | |
| SCHEMBL17438356 | 0.90 | EGFR (0.61) | EGFR | |
| SCHEMBL17438322 | 0.90 | EGFR (0.61) | EGFR | |
| SCHEMBL17438321 | 0.90 | EGFR (0.61) | EGFR | |
| SCHEMBL17438502 | 0.89 | EGFR (0.62) | EGFRERBB2 | |
| SCHEMBL17438504 | 0.89 | EGFR (0.62) | EGFRERBB2 | |
| SCHEMBL17447772 | 0.88 | EGFR (0.57) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890152-B2 | Aminopyrimidine compounds as inhibitors of T790M containing EGFR mutants | GENENTECH, INC. (US) | 2018-02-13 | — | — | US | disclosed |