Elamipretide

Elamipretide

SCHEMBL19862103

Cc1cc(O)cc(C)c1CC(NC(=O)[C@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O

nearest known ligand 0.64

Full drug profile on Sugi Atlas →

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
NPY4R P50391 12/20 0.64
NPY1R P25929 7/20 0.64
NPY2R P49146 5/20 0.64
NPY5R Q15761 5/20 0.64
OPRM1 P35372 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Elamipretide SCHEMBL17374160 1.00 NPY4R (0.64) NPY4RNPY1RNPY2RNPY5ROPRM1
Elamipretide SCHEMBL21627153 1.00 NPY4R (0.64) NPY4RNPY1RNPY2RNPY5ROPRM1
Elamipretide SCHEMBL17374162 1.00 NPY4R (0.64) NPY4RNPY1RNPY2RNPY5ROPRM1
Elamipretide SCHEMBL23192356 1.00 NPY4R (0.64) NPY4RNPY1RNPY2RNPY5ROPRM1
Elamipretide SCHEMBL15028020 1.00 NPY4R (0.64) NPY4RNPY1RNPY2RNPY5ROPRM1
Elamipretide SCHEMBL23842427 1.00 NPY4R (0.64) NPY4RNPY1RNPY2RNPY5ROPRM1
Elamipretide SCHEMBL18384105 1.00 NPY4R (0.64) NPY4RNPY1RNPY2RNPY5ROPRM1
Elamipretide SCHEMBL29414484 0.99 NPY4R (0.63) NPY4RNPY1RNPY2RNPY5ROPRM1
SCHEMBL18912830 0.99 NPY4R (0.63) NPY4RNPY1RNPY2RNPY5ROPRM1
SCHEMBL26179137 0.98 NPY4R (0.62) NPY4RNPY1RNPY2RNPY5ROPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3087093-B1 PHARMACEUTICALLY RELEVANT AROMATIC-CATIONIC PEPTIDES STEALTH BIOTHERAPEUTICS CORP (MC) 2021-11-10 EP disclosed
US-10633415-B2 Processes for preparing pharmaceutically relevant peptides STEALTH BIOTHERAPEUTICS CORP (MC) 2020-04-28 US disclosed
US-20180044378-A1 PROCESSES FOR PREPARING PHARMACEUTICALLY RELEVANT PEPTIDES STEALTH BIOTHERAPEUTICS INC. 2018-02-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180044378-A1 PROCESSES FOR PREPARING PHARMACEUTICALLY RELEVANT PEPTIDES ADM2, VIP, PEPD NPY4R 135/4885NPY1R 140/4885NPY2R 76/4885
US-10633415-B2 Processes for preparing pharmaceutically relevant peptides ADM2, VIP, PEPD NPY4R 135/4885NPY1R 140/4885NPY2R 76/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.