SCHEMBL19862656

SCHEMBL19862656

C=C(C)C(=O)OCCNC(=O)c1c(F)c(F)c(S(=O)(=O)OC(C(=O)c2ccccc2)C(F)(F)F)c(F)c1F

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.34
CYP3A4 P08684 3/20 0.33
CYP1A2 P05177 2/20 0.33
KMT2A Q03164 2/20 0.33
MEN1 O00255 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
HPGD P15428 3/20 0.32
ALDH1A1 P00352 1/20 0.32
TSHR P16473 1/20 0.31
RECQL P46063 1/20 0.31
USP2 O75604 3/20 0.31
NR1I2 O75469 1/20 0.31
ADRB1 P08588 1/20 0.31
HTR1A P08908 1/20 0.31
ADRA2A P08913 1/20 0.31
ADORA3 P0DMS8 1/20 0.31
ADRA2B P18089 1/20 0.31
ADRA2C P18825 1/20 0.31
CHRM3 P20309 1/20 0.31
SLC6A2 P23975 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19862668 0.90 SMN1; SMN2 (0.37) SMN1; SMN2CYP3A4CYP1A2KMT2AMEN1
SCHEMBL19862667 0.80 POLB (0.33) SMN1; SMN2CYP3A4CYP1A2KMT2AMEN1
SCHEMBL17447748 0.73 RECQL (0.43) CYP3A4CYP1A2KMT2AMEN1ALDH1A1
SCHEMBL19862655 0.72 CYP3A4 (0.34) SMN1; SMN2CYP3A4CYP1A2KMT2AMEN1
SCHEMBL19862653 0.72 ELANE (0.35) CYP3A4NPSR1ALDH1A1TSHRPOLB
SCHEMBL17461711 0.70 KDM4E (0.41) CYP3A4CYP1A2KMT2AMEN1NPSR1
Phosphoric Acid SCHEMBL7716499 0.68 SMN1; SMN2 (0.59) SMN1; SMN2CYP3A4CYP1A2KMT2AMEN1
SCHEMBL19862674 0.67 CYP3A4 (0.34) SMN1; SMN2CYP3A4CYP1A2KMT2AMEN1
SCHEMBL8016168 0.66 KMT2A (0.53) SMN1; SMN2CYP3A4CYP1A2KMT2AMEN1
SCHEMBL14368851 0.65 NPC1 (0.55) SMN1; SMN2CYP3A4CYP1A2KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9951164-B2 Non-ionic aryl ketone based polymeric photo-acid generators INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2018-04-24 US disclosed
US-9951164-B2 Non-ionic aryl ketone based polymeric photo-acid generators INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2018-04-24 US disclosed
US-20180044459-A1 NON-IONIC ARYL KETONE BASED POLYMERIC PHOTO-ACID GENERATORS CENTRAL GLASS CO., LTD. (JP) 2018-02-15 US disclosed
US-20180044459-A1 NON-IONIC ARYL KETONE BASED POLYMERIC PHOTO-ACID GENERATORS CENTRAL GLASS CO., LTD. (JP) 2018-02-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180044459-A1 NON-IONIC ARYL KETONE BASED POLYMERIC PHOTO-ACID GENERATORS PPARG, PPARA, PPARD SMN1; SMN2 4519/4885CYP3A4 763/4885CYP1A2 875/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.