Sugi Predict

Sugi Predict / Compounds / SCHEMBL19863716

SCHEMBL19863716

SCHEMBL19863716

CS(=O)(=O)N1CCC(Nc2ncc3cc(C(F)F)c(=O)n([C@@H]4CCC[C@@H](O)C4)c3n2)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ CCNE1 P24864 20/20 1.00
▸ CDK2 P24941 20/20 1.00
▸ CCND1 P24385 19/20 1.00
▸ CDK6 Q00534 19/20 1.00
▸ CCNT1 O60563 1/20 0.71
▸ CCNE2 O96020 1/20 0.71
▸ RB1 P06400 1/20 0.71
▸ CDK1 P06493 1/20 0.71
▸ CDK4 P11802 1/20 0.71
▸ CCNA2 P20248 1/20 0.71
▸ CCND3 P30281 1/20 0.71
▸ CDK9 P50750 1/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29798900 0.96 CCNE1 (1.00) CCNE1CDK2CCND1CDK6
SCHEMBL19863595 0.96 CCNE1 (1.00) CCNE1CDK2CCND1CDK6
SCHEMBL19857325 0.96 CCNE1 (1.00) CCNE1CDK2CCND1CDK6
SCHEMBL19863604 0.91 CCNE1 (1.00) CCNE1CDK2CCND1CDK6CCNT1
SCHEMBL29508810 0.90 CCNE1 (0.86) CCNE1CDK2CCND1CDK6CCNT1
SCHEMBL23290057 0.89 CCNE1 (1.00) CCNE1CDK2CCND1CDK6CCNT1
SCHEMBL19863606 0.89 CCNE1 (1.00) CCNE1CDK2CCND1CDK6CCNT1
SCHEMBL19863605 0.89 CCNE1 (1.00) CCNE1CDK2CCND1CDK6CCNT1
SCHEMBL19863608 0.88 CCNE1 (1.00) CCNE1CDK2CCND1CDK6CCNT1
SCHEMBL19863607 0.88 CCNE1 (1.00) CCNE1CDK2CCND1CDK6CCNT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11396512-B2 CDK2/4/6 inhibitors PFIZER INC. (US) 2022-07-26 — — US disclosed
EP-3497103-B1 PYRIDOPYRIMDINONE CDK2/4/6 INHIBITORS PFIZER (US) 2021-05-05 — — EP disclosed
US-20200392142-A1 CDK2/4/6 Inhibitors PFIZER INC. (US) 2020-12-17 — — US disclosed
US-10800783-B2 CDK2/4/6 inhibitors PFIZER INC. (US) 2020-10-13 — — US disclosed
US-20190135817-A1 CDK2/4/6 Inhibitors PFIZER INC. (US) 2019-05-09 — — US disclosed
US-10233188-B2 CDK2/4/6 inhibitors PFIZER INC. (US) 2019-03-19 — — US disclosed
US-20180044344-A1 CDK2/4/6 Inhibitors PFIZER INC. (US) 2018-02-15 — — US disclosed
US-20180044344-A1 CDK2/4/6 Inhibitors PFIZER INC. (US) 2018-02-15 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200392142-A1 CDK2/4/6 Inhibitors CDK2, CDK6, CDK20 CCNE1 28/4885CDK2 1/4885CCND1 39/4885
US-11396512-B2 CDK2/4/6 inhibitors CDK2, CDK6, CDK20 CCNE1 29/4885CDK2 1/4885CCND1 40/4885
US-10800783-B2 CDK2/4/6 inhibitors CDK2, CDK6, CDK20 CCNE1 29/4885CDK2 1/4885CCND1 40/4885
US-20180044344-A1 CDK2/4/6 Inhibitors CDK2, CDK6, CDK20 CCNE1 29/4885CDK2 1/4885CCND1 40/4885
US-20190135817-A1 CDK2/4/6 Inhibitors CDK2, CDK6, CDK20 CCNE1 29/4885CDK2 1/4885CCND1 40/4885
US-10233188-B2 CDK2/4/6 inhibitors CDK2, CDK6, CDK20 CCNE1 29/4885CDK2 1/4885CCND1 40/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.