Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 19/20 | 0.38 |
| ▸ | VEGFA | P15692 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ARNT | P27540 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19865432 | 0.79 | EPAS1 (0.57) | EPAS1VEGFACYP2C9ARNTCYP2C19 | |
| SCHEMBL19865439 | 0.79 | EPAS1 (0.38) | EPAS1VEGFACYP2C9ARNTCYP2C19 | |
| SCHEMBL19865219 | 0.78 | EPAS1 (0.44) | EPAS1VEGFACYP2C9ARNTCYP2C19 | |
| SCHEMBL19865226 | 0.76 | EPAS1 (0.49) | EPAS1VEGFACYP2C9ARNTCYP2C19 | |
| SCHEMBL19865195 | 0.72 | NPC1 (0.32) | — | |
| SCHEMBL19872298 | 0.70 | EPAS1 (0.65) | EPAS1VEGFACYP2C9ARNTCYP2C19 | |
| SCHEMBL20182727 | 0.70 | EPAS1 (0.65) | EPAS1VEGFACYP2C9ARNTCYP2C19 | |
| SCHEMBL24910449 | 0.70 | EPAS1 (0.39) | EPAS1VEGFACYP2C9ARNTCYP2C19 | |
| SCHEMBL19865455 | 0.69 | EPAS1 (0.63) | EPAS1VEGFA | |
| SCHEMBL19872283 | 0.68 | EPAS1 (0.64) | EPAS1VEGFA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018031680-A1 | NOVEL COMPOUNDS, USES AND METHODS FOR THEIR PREPARATION | FRONTHERA U.S. PHARMACEUTICALS LLC (US) | 2018-02-15 | — | — | WO | disclosed |