Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMX | P51813 | 10/20 | 0.57 |
| ▸ | TNK2 | Q07912 | 9/20 | 0.54 |
| ▸ | MAP4K2 | Q12851 | 9/20 | 0.54 |
| ▸ | ABL1 | P00519 | 3/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | FES | P07332 | 1/20 | 0.50 |
| ▸ | RET | P07949 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | KIT | P10721 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | FLT1 | P17948 | 1/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.50 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.50 |
| ▸ | TEK | Q02763 | 1/20 | 0.50 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.50 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19865444 | 0.87 | TNK2 (0.73) | BMXTNK2MAP4K2ABL1LCK | |
| SCHEMBL19929613 | 0.86 | TNK2 (0.65) | BMXTNK2MAP4K2ABL1BCR | |
| SCHEMBL19929614 | 0.85 | TNK2 (0.63) | BMXTNK2MAP4K2ABL1LCK | |
| SCHEMBL19922800 | 0.83 | BMX (0.60) | BMXTNK2MAP4K2ABL1LCK | |
| SCHEMBL19922711 | 0.82 | TNK2 (0.70) | BMXTNK2MAP4K2ABL1LCK | |
| SCHEMBL19922638 | 0.81 | TNK2 (0.68) | BMXTNK2MAP4K2ABL1LCK | |
| SCHEMBL19922640 | 0.81 | TNK2 (0.69) | BMXTNK2MAP4K2ABL1LCK | |
| SCHEMBL19922719 | 0.80 | TNK2 (0.57) | BMXTNK2MAP4K2ABL1LCK | |
| SCHEMBL19922732 | 0.80 | TNK2 (0.70) | BMXTNK2MAP4K2ABL1LCK | |
| SCHEMBL19922758 | 0.79 | TNK2 (0.78) | BMXTNK2MAP4K2ABL1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10059717-B2 | Urea compounds containing 3,4-dihydropyrimido[4,5-D]pyrimidin-2(1H)-one skeleton as protein kinase inhibitors | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2018-08-28 | — | — | US | disclosed |
| US-20180065970-A1 | UREA COMPOUNDS CONTAINING 3,4-DIHYDROPYRIMIDO[4,5-D]PYRIMIDIN-2(1H)-ONE SKELETON AS PROTEIN KINASE INHIBITORS | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2018-03-08 | — | — | US | disclosed |
| US-20180065970-A1 | UREA COMPOUNDS CONTAINING 3,4-DIHYDROPYRIMIDO[4,5-D]PYRIMIDIN-2(1H)-ONE SKELETON AS PROTEIN KINASE INHIBITORS | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2018-03-08 | — | — | US | disclosed |
| US-20180065970-A1 | UREA COMPOUNDS CONTAINING 3,4-DIHYDROPYRIMIDO[4,5-D]PYRIMIDIN-2(1H)-ONE SKELETON AS PROTEIN KINASE INHIBITORS | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2018-03-08 | — | — | US | disclosed |
| WO-2018030800-A1 | UREA COMPOUND HAVING 3,4-DIHYDROPYRIMIDO[4,5-D]PYRIMIDINE-2(1H)-ONE SKELETON HAVING PROTEIN KINASE INHIBITING ACTIVITY | 한국과학기술연구원 | 2018-02-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10059717-B2 | Urea compounds containing 3,4-dihydropyrimido[4,5-D]pyrimidin-2(1H)-one skeleton as protein kinase inhibitors | MAP4K2, CMPK1, MTOR | BMX 1107/4885TNK2 230/4885MAP4K2 1/4885 |
| US-20180065970-A1 | UREA COMPOUNDS CONTAINING 3,4-DIHYDROPYRIMIDO[4,5-D]PYRIMIDIN-2(1H)-ONE SKELETON AS PROTEIN KINASE INHIBITORS | MAP4K2, CMPK1, MTOR | BMX 1107/4885TNK2 230/4885MAP4K2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.