Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20281240 | 0.94 | SMN1; SMN2 (0.46) | SMN1; SMN2MEN1KMT2ACHRM2HRH4 | |
| SCHEMBL19865638 | 0.83 | CHRM2 (0.46) | SMN1; SMN2MEN1KMT2ACHRM2HRH4 | |
| SCHEMBL2260570 | 0.80 | KDM1A (0.47) | LMNAKDM1AMAOAMAOB | |
| SCHEMBL31064603 | 0.80 | KDM1A (0.51) | CYP1A2CYP2D6KDM1AMAOAMAOB | |
| SCHEMBL5452167 | 0.79 | TDP1 (0.47) | SMN1; SMN2LMNAKDM1AMAOAMAOB | |
| SCHEMBL22166126 | 0.79 | TDP1 (0.47) | SMN1; SMN2LMNAKDM1AMAOAMAOB | |
| SCHEMBL19304381 | 0.79 | TDP1 (0.47) | SMN1; SMN2LMNAKDM1AMAOAMAOB | |
| SCHEMBL21076459 | 0.79 | TDP1 (0.47) | SMN1; SMN2LMNAKDM1AMAOAMAOB | |
| SCHEMBL6668385 | 0.77 | TDP1 (0.49) | SMN1; SMN2LMNACYP2D6CYP2C19KDM1A | |
| SCHEMBL16269117 | 0.77 | CYP2C19 (0.44) | SMN1; SMN2MEN1KMT2ACYP2C19KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180044343-A1 | BICYCLIC IMIDAZOLO DERIVATIVE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2018-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180044343-A1 | BICYCLIC IMIDAZOLO DERIVATIVE | PDE3A, PDE2A, PDE5A | SMN1; SMN2 2225/4885MEN1 3475/4885KMT2A 3580/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.