Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 13/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 4/20 | 0.39 |
| ▸ | DRD3 | P35462 | 4/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19867147 | 1.00 | DRD4 (0.43) | DRD4CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL13551809 | 1.00 | DRD4 (0.43) | DRD4CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL22623916 | 0.88 | DRD4 (0.42) | DRD4CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL1943731 | 0.82 | DRD4 (0.44) | DRD4EPHX2HRH3 | |
| SCHEMBL25947642 | 0.80 | DRD4 (0.47) | DRD4CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL9228792 | 0.80 | SLC6A2 (0.50) | DRD4CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL19075582 | 0.79 | DRD4 (0.37) | DRD4CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL9641488 | 0.78 | HRH3 (0.64) | DRD4DRD2DRD3EPHX2HRH3 | |
| Hydrochloric Acid SCHEMBL10981595 | 0.78 | SLC6A2 (0.49) | DRD4CYP1A2CYP3A4CYP2D6CYP2C9 | |
| Hydrochloric Acid SCHEMBL9640901 | 0.77 | HRH3 (0.62) | DRD4DRD2DRD3EPHX2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210196724-A1 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | ATHENEX, INC. | 2021-07-01 | — | — | US | disclosed |
| US-10973828-B2 | Biaryl compositions and methods for modulating a kinase cascade | ATHENEX, INC. (US) | 2021-04-13 | — | — | US | disclosed |
| US-20190125754-A1 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | OAKTREE FUND ADMINISTRATION, LLC | 2019-05-02 | — | — | US | disclosed |
| US-20180042934-A1 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | OAKTREE FUND ADMINISTRATION, LLC | 2018-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180042934-A1 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | PLK1, MAP3K2, TNK2 | DRD4 4712/4885CYP1A2 3857/4885CYP3A4 4125/4885 |
| US-20190125754-A1 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | PLK1, MAP3K2, TNK2 | DRD4 4712/4885CYP1A2 3857/4885CYP3A4 4125/4885 |
| US-10973828-B2 | Biaryl compositions and methods for modulating a kinase cascade | PLK1, MAP3K2, TNK2 | DRD4 4712/4885CYP1A2 3857/4885CYP3A4 4125/4885 |
| US-20210196724-A1 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | PLK1, MAP3K2, TNK2 | DRD4 4712/4885CYP1A2 3857/4885CYP3A4 4125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.