Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNKSR1 | Q969H4 | 11/20 | 0.65 |
| ▸ | AKT1 | P31749 | 3/20 | 0.58 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15811538 | 0.83 | CNKSR1 (0.70) | CNKSR1AKT1PKMHSD17B10PGAM1 | |
| SCHEMBL18147993 | 0.83 | CNKSR1 (0.70) | CNKSR1AKT1PKMHSD17B10PGAM1 | |
| SCHEMBL20798601 | 0.82 | CNKSR1 (0.67) | CNKSR1AKT1PKMHSD17B10PGAM1 | |
| SCHEMBL18148216 | 0.82 | CNKSR1 (0.67) | CNKSR1AKT1PKMHSD17B10PGAM1 | |
| SCHEMBL15811533 | 0.82 | CNKSR1 (0.67) | CNKSR1AKT1PKMHSD17B10PGAM1 | |
| SCHEMBL18148094 | 0.79 | CNKSR1 (0.65) | CNKSR1AKT1PKMHSD17B10PGAM1 | |
| SCHEMBL18148081 | 0.79 | CNKSR1 (0.65) | CNKSR1AKT1PKMHSD17B10PGAM1 | |
| SCHEMBL15811543 | 0.79 | CNKSR1 (0.65) | CNKSR1AKT1PKMHSD17B10PGAM1 | |
| SCHEMBL15811544 | 0.79 | CNKSR1 (0.65) | CNKSR1AKT1PKMHSD17B10PGAM1 | |
| SCHEMBL15811542 | 0.79 | CNKSR1 (0.65) | CNKSR1AKT1PKMHSD17B10PGAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2931280-B1 | METHODS AND COMPOSITIONS FOR INHIBITING CNKSR1 | PHUSIS THERAPEUTICS INC (US) | 2018-02-14 | — | — | EP | disclosed |