Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNKSR1 | Q969H4 | 13/20 | 0.58 |
| ▸ | AKT1 | P31749 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15811504 | 0.84 | CNKSR1 (0.81) | CNKSR1AKT1SMN1; SMN2ALDH1A1BCL2A1 | |
| SCHEMBL17200780 | 0.83 | CNKSR1 (0.76) | CNKSR1AKT1SMN1; SMN2ALDH1A1BCL2A1 | |
| SCHEMBL20798600 | 0.83 | CNKSR1 (0.76) | CNKSR1AKT1SMN1; SMN2ALDH1A1BCL2A1 | |
| SCHEMBL15811477 | 0.83 | CNKSR1 (0.76) | CNKSR1AKT1SMN1; SMN2ALDH1A1BCL2A1 | |
| SCHEMBL17211718 | 0.80 | CNKSR1 (0.64) | CNKSR1AKT1SMN1; SMN2ALDH1A1BCL2A1 | |
| SCHEMBL18160892 | 0.80 | CNKSR1 (0.64) | CNKSR1AKT1SMN1; SMN2ALDH1A1BCL2A1 | |
| SCHEMBL17211661 | 0.79 | CNKSR1 (0.63) | CNKSR1AKT1SMN1; SMN2ALDH1A1BCL2A1 | |
| SCHEMBL18160885 | 0.79 | CNKSR1 (0.75) | CNKSR1AKT1SMN1; SMN2ALDH1A1BCL2A1 | |
| SCHEMBL18160896 | 0.78 | CNKSR1 (0.67) | CNKSR1AKT1SMN1; SMN2ALDH1A1BCL2A1 | |
| SCHEMBL17211657 | 0.77 | CNKSR1 (0.60) | CNKSR1AKT1SMN1; SMN2ALDH1A1BCL2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2931280-B1 | METHODS AND COMPOSITIONS FOR INHIBITING CNKSR1 | PHUSIS THERAPEUTICS INC (US) | 2018-02-14 | — | — | EP | disclosed |