Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | SLC10A1 | Q14973 | 9/20 | 0.39 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.36 |
| ▸ | F11 | P03951 | 1/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.34 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16421503 | 1.00 | GRM4 (0.41) | GRM4SLC10A1FSCN1F11KLKB1 | |
| SCHEMBL17838271 | 0.87 | SLC10A1 (0.44) | GRM4SLC10A1FSCN1F11KLKB1 | |
| SCHEMBL20455511 | 0.86 | GRM4 (0.40) | GRM4SLC10A1PGRAR | |
| SCHEMBL17838304 | 0.86 | GRM4 (0.40) | GRM4SLC10A1PGRAR | |
| SCHEMBL22511118 | 0.84 | GRM4 (0.43) | GRM4SLC10A1FSCN1IMPDH2KCNH2 | |
| SCHEMBL19881930 | 0.84 | GRM4 (0.40) | GRM4SLC10A1FSCN1IMPDH2AR | |
| SCHEMBL16421490 | 0.84 | GRM4 (0.41) | GRM4SLC10A1FSCN1PGRAR | |
| SCHEMBL22380458 | 0.83 | GRM4 (0.47) | GRM4SLC10A1FSCN1IMPDH2 | |
| SCHEMBL16416934 | 0.83 | GRM4 (0.43) | GRM4SLC10A1FSCN1IMPDH2PGR | |
| SCHEMBL16421480 | 0.83 | SLC10A1 (0.45) | GRM4SLC10A1FSCN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3357906-A1 | GLYOXAMIDE SUBSTITUTED PYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | Janssen Sciences Ireland UC (IE) | 2018-08-08 | — | — | EP | disclosed |
| EP-3024819-B1 | GLYOXAMIDE SUBSTITUTED PYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | JANSSEN SCIENCES IRELAND UC (IE) | 2018-02-21 | — | — | EP | disclosed |