SCHEMBL19873178

SCHEMBL19873178

CC(NC(=O)C(=O)c1c(Br)c(C(=O)Nc2ccc(F)c(C#N)c2)n(C)c1Br)C(F)(F)F

nearest known ligand 0.49

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SLC10A1 Q14973 18/20 0.49
GRM4 Q14833 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17838298 1.00 SLC10A1 (0.49) SLC10A1GRM4
SCHEMBL17838300 0.91 SLC10A1 (0.51) SLC10A1GRM4
SCHEMBL19873174 0.85 SLC10A1 (0.46) SLC10A1GRM4
SCHEMBL17838309 0.84 SLC10A1 (0.43) SLC10A1GRM4
SCHEMBL17838299 0.84 SLC10A1 (0.51) SLC10A1GRM4
SCHEMBL17838284 0.84 SLC10A1 (0.51) SLC10A1GRM4
SCHEMBL17838279 0.83 SLC10A1 (0.52) SLC10A1GRM4
SCHEMBL16421457 0.83 GRM4 (0.45) SLC10A1GRM4
SCHEMBL17838303 0.83 GRM4 (0.40) SLC10A1GRM4
SCHEMBL21408544 0.81 SLC10A1 (0.49) SLC10A1GRM4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3024819-B1 GLYOXAMIDE SUBSTITUTED PYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B JANSSEN SCIENCES IRELAND UC (IE) 2018-02-21 EP disclosed