Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.34 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.34 |
| ▸ | NAAA | Q02083 | 1/20 | 0.31 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19873555 | 0.91 | LPAR1 (0.34) | APPLPAR1LPAR3NAAAAKR1C3 | |
| SCHEMBL19873553 | 0.91 | LPAR1 (0.34) | APPLPAR1LPAR3NAAAAKR1C3 | |
| SCHEMBL19873559 | 0.90 | LPAR1 (0.37) | APPLPAR1LPAR3NAAA | |
| SCHEMBL19873600 | 0.90 | LPAR1 (0.37) | APPLPAR1LPAR3NAAA | |
| SCHEMBL19873542 | 0.89 | APP (0.37) | APPLPAR1LPAR3NAAAAKR1C3 | |
| SCHEMBL19873541 | 0.89 | APP (0.37) | APPLPAR1LPAR3NAAAAKR1C3 | |
| SCHEMBL19873569 | 0.89 | LPAR1 (0.43) | APPLPAR1LPAR3NAAAAKR1C3 | |
| SCHEMBL19873568 | 0.89 | LPAR1 (0.43) | APPLPAR1LPAR3NAAAAKR1C3 | |
| SCHEMBL19873649 | 0.88 | APP (0.40) | APPLPAR1LPAR3NAAAAKR1C3 | |
| SCHEMBL19873572 | 0.88 | CHRM3 (0.37) | APPLPAR1LPAR3NAAAAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3360869-B1 | HALOGEN-SUBSTITUTED HETEROCYCLIC COMPOUND USEFUL FOR THE TREATMENT OF DISEASES CAUSED BY LPA. | UBE INDUSTRIES (JP) | 2020-07-29 | — | — | EP | claimed |
| EP-2940013-B1 | HALOGEN-SUBSTITUTED HETEROCYCLIC COMPOUND | UBE INDUSTRIES (JP) | 2018-02-21 | — | — | EP | claimed |