Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GALR3 | O60755 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PGD | P52209 | 2/20 | 0.33 |
| ▸ | PRKCA | P17252 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15984383 | 0.92 | TDP1 (0.40) | TSHRTDP1TRPV1CHRM2CHRM4 | |
| SCHEMBL12958786 | 0.86 | TSHR (0.48) | TSHRTDP1TRPV1CHRM2CHRM4 | |
| SCHEMBL19879374 | 0.82 | TSHR (0.44) | TSHRTDP1TRPV1CHRM2CHRM4 | |
| SCHEMBL19879376 | 0.81 | TDP1 (0.38) | TSHRTDP1TRPV1CHRM2CHRM4 | |
| SCHEMBL756656 | 0.78 | TSHR (0.50) | TSHRTDP1TRPV1CHRM2CHRM4 | |
| SCHEMBL1698005 | 0.76 | TSHR (0.48) | TSHRTDP1TRPV1CHRM2CHRM4 | |
| SCHEMBL1232896 | 0.76 | TSHR (0.48) | TSHRTDP1TRPV1CHRM2CHRM4 | |
| SCHEMBL17358635 | 0.74 | TSHR (0.50) | TSHRTDP1TRPV1CHRM2CHRM4 | |
| SCHEMBL25304459 | 0.74 | TDP1 (0.47) | TSHRTDP1TRPV1CHRM2CHRM4 | |
| SCHEMBL28084580 | 0.73 | TRPV1 (0.44) | TSHRTDP1TRPV1CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9895384-B1 | Abuse deterrent opioid agonist transdermal compositions and methods for their use | INTEGURX THERAPEUTICS, LLC (US) | 2018-02-20 | — | — | US | disclosed |