Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19415579 | 1.00 | HDAC4 (0.31) | HDAC4HDAC2HDAC8HDAC6CYP3A4 | |
| SCHEMBL7077446 | 0.98 | — | — | |
| SCHEMBL8041794 | 0.91 | — | — | |
| SCHEMBL28221603 | 0.85 | — | — | |
| SCHEMBL9743672 | 0.79 | KDM1A (0.31) | HDAC4HDAC2HDAC8HDAC6 | |
| SCHEMBL17353416 | 0.79 | — | — | |
| SCHEMBL20572803 | 0.78 | — | — | |
| SCHEMBL20572958 | 0.76 | — | — | |
| SCHEMBL6049831 | 0.76 | — | — | |
| SCHEMBL9351364 | 0.74 | KDM1A (0.33) | HDAC4HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9896435-B2 | N-pyrrolidinyl,N′-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2018-02-20 | — | — | US | disclosed |