Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 13/20 | 0.41 |
| ▸ | PARP1 | P09874 | 8/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19882186 | 0.82 | TNKS (0.40) | TNKSPARP1TNKS2PIM1ATM | |
| SCHEMBL16569747 | 0.80 | TNKS (0.49) | TNKSPARP1TNKS2 | |
| SCHEMBL16578887 | 0.76 | PRMT5 (0.44) | TNKSPARP1TNKS2 | |
| SCHEMBL16569813 | 0.75 | PARP1 (0.47) | TNKSPARP1TNKS2PIM1ATM | |
| SCHEMBL16578832 | 0.74 | TNKS (0.47) | TNKSPARP1TNKS2 | |
| SCHEMBL16569699 | 0.73 | TNKS (0.42) | TNKSPARP1TNKS2 | |
| SCHEMBL16569744 | 0.72 | TNKS (0.72) | TNKSPARP1PIM1 | |
| SCHEMBL19882184 | 0.72 | TNKS (0.49) | TNKSPARP1TNKS2PIM1 | |
| SCHEMBL16578844 | 0.71 | PRKACA (0.44) | TNKSPARP1 | |
| SCHEMBL16569773 | 0.71 | TNKS (0.74) | TNKSPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3044221-B1 | 3-ARYL-5-SUBSTITUTED-ISOQUINOLIN-1-ONE COMPOUNDS AND THEIR THERAPEUTIC USE | INST OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (THE) (GB) | 2018-02-21 | — | — | EP | disclosed |