Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 9/20 | 0.53 |
| ▸ | PARP1 | P09874 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 10/20 | 0.51 |
| ▸ | RAB9A | P51151 | 10/20 | 0.51 |
| ▸ | TP53 | P04637 | 9/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.51 |
| ▸ | LMNA | P02545 | 6/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 5/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 5/20 | 0.51 |
| ▸ | RELA | Q04206 | 5/20 | 0.51 |
| ▸ | PKM | P14618 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11924524 | 0.84 | TSHR (0.63) | TSHRMAPTPARP1NPC1RAB9A | |
| SCHEMBL659214 | 0.78 | TSHR (0.71) | TSHRMAPTPARP1NPC1RAB9A | |
| SCHEMBL7955024 | 0.78 | TSHR (0.67) | TSHRMAPTPARP1NPC1RAB9A | |
| SCHEMBL11220484 | 0.76 | TSHR (0.65) | TSHRMAPTPARP1NPC1RAB9A | |
| SCHEMBL13278295 | 0.76 | TSHR (0.64) | TSHRMAPTPARP1NPC1RAB9A | |
| Potassium Ion SCHEMBL11217723 | 0.75 | TSHR (0.63) | TSHRMAPTPARP1NPC1RAB9A | |
| SCHEMBL13035816 | 0.74 | TSHR (0.67) | TSHRMAPTPARP1NPC1RAB9A | |
| SCHEMBL24026375 | 0.74 | PARP1 (0.67) | TSHRMAPTPARP1NPC1RAB9A | |
| SCHEMBL9891915 | 0.74 | TSHR (0.66) | TSHRMAPTPARP1NPC1RAB9A | |
| SCHEMBL6999293 | 0.74 | TSHR (0.61) | TSHRMAPTPARP1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190293641-A1 | ASSAY | IMPERIAL COLLEGE INNOVATIONS, LTD. (GB) | 2019-09-26 | — | — | US | disclosed |
| WO-2018033753-A2 | ASSAY | IMPERIAL INNOVATIONS LIMITED (GB) | 2018-02-22 | — | — | WO | disclosed |