Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 18/20 | 0.87 |
| ▸ | INSR | P06213 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18181693 | 0.93 | ALK (1.00) | ALKINSRKCNH2EGFR | |
| SCHEMBL19895210 | 0.89 | ALK (0.69) | ALKINSRKCNH2EGFR | |
| SCHEMBL18181711 | 0.88 | ALK (1.00) | ALKEGFR | |
| SCHEMBL18181728 | 0.86 | ALK (0.88) | ALKINSRKCNH2 | |
| SCHEMBL19895166 | 0.84 | ALK (0.66) | ALKINSR | |
| SCHEMBL18181663 | 0.83 | ALK (0.79) | ALKINSRKCNH2EGFR | |
| SCHEMBL15283080 | 0.81 | ALK (0.83) | ALK | |
| SCHEMBL18181618 | 0.80 | ALK (1.00) | ALKEGFR | |
| SCHEMBL15283503 | 0.79 | ALK (0.87) | ALK | |
| SCHEMBL18181619 | 0.79 | ALK (1.00) | ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111440189-B | Fused ring pyrimidine amino derivative, preparation method, intermediate, pharmaceutical composition and application thereof | 广州再极医药科技有限公司 | 2022-08-09 | — | — | CN | disclosed |
| CN-110078741-B | Fused ring pyrimidine amino derivative, preparation method, intermediate, pharmaceutical composition and application thereof | 广州再极医药科技有限公司 | 2021-10-01 | — | — | CN | disclosed |
| CN-106220644-B | Fused ring pyrimidine amino derivative, preparation method, intermediate, pharmaceutical composition and application thereof | 广州再极医药科技有限公司 | 2020-07-31 | — | — | CN | disclosed |
| CN-111440189-A | Fused ring pyrimidine amino derivative, preparation method, intermediate, pharmaceutical composition and application thereof | 广州再极医药科技有限公司 | 2020-07-24 | — | — | CN | disclosed |
| EP-3287463-A1 | CONDENSED-RING PYRIMIDYLAMINO DERIVATIVE, PREPARATION METHOD THEREFOR, AND INTERMEDIATE, PHARMACEUTICAL COMPOSITION AND APPLICATIONS THEREOF | Guangzhou Maxinovel Pharmaceuticals Co., Ltd. (CN) | 2018-02-28 | — | — | EP | disclosed |