Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 20/20 | 0.66 |
| ▸ | PKD1 | P98161 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20916168 | 0.86 | MAP3K14 (0.83) | MAP3K14PKD1 | |
| SCHEMBL19912127 | 0.79 | MAP3K14 (1.00) | MAP3K14PKD1 | |
| SCHEMBL20916215 | 0.79 | MAP3K14 (1.00) | MAP3K14PKD1 | |
| SCHEMBL29450144 | 0.79 | MAP3K14 (1.00) | MAP3K14PKD1 | |
| SCHEMBL19912052 | 0.79 | MAP3K14 (1.00) | MAP3K14PKD1 | |
| SCHEMBL19912135 | 0.79 | MAP3K14 (1.00) | MAP3K14PKD1 | |
| SCHEMBL20927177 | 0.79 | MAP3K14 (1.00) | MAP3K14PKD1 | |
| SCHEMBL20916219 | 0.79 | MAP3K14 (1.00) | MAP3K14PKD1 | |
| SCHEMBL29948039 | 0.79 | MAP3K14 (1.00) | MAP3K14PKD1 | |
| SCHEMBL19899700 | 0.72 | MAP3K14 (0.51) | MAP3K14PKD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504206-A1 | 2-AZABICYCLO[3.1.0]HEXAN-3-ONE DERIVATIVES AND METHODS OF USE | H. Hoffnabb-La Roche Ag (CH) | 2019-07-03 | — | — | EP | disclosed |
| WO-2018037059-A1 | 2-AZABICYCLO[3.1.0]HEXAN-3-ONE DERIVATIVES AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2018-03-01 | — | — | WO | disclosed |