Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 20/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.66 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.66 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.66 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.66 |
| ▸ | CLK1 | P49759 | 1/20 | 0.66 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.66 |
| ▸ | PRKG2 | Q13237 | 2/20 | 0.60 |
| ▸ | CIT | O14578 | 2/20 | 0.60 |
| ▸ | GAK | O14976 | 2/20 | 0.60 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.60 |
| ▸ | BMP2K | Q9NSY1 | 2/20 | 0.60 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.60 |
| ▸ | GSK3A | P49840 | 1/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.58 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | MYLK2 | Q9H1R3 | 1/20 | 0.58 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30061130 | 1.00 | AAK1 (1.00) | AAK1CYP3A4MKNK2ROCK2NR2C2 | |
| SCHEMBL17155390 | 1.00 | AAK1 (1.00) | AAK1CYP3A4MKNK2ROCK2NR2C2 | |
| SCHEMBL30059520 | 0.87 | AAK1 (1.00) | AAK1CYP3A4MKNK2ROCK2NR2C2 | |
| SCHEMBL19901184 | 0.87 | AAK1 (1.00) | AAK1CYP3A4MKNK2ROCK2NR2C2 | |
| SCHEMBL17155471 | 0.87 | AAK1 (1.00) | AAK1CYP3A4MKNK2ROCK2NR2C2 | |
| SCHEMBL20447182 | 0.86 | AAK1 (1.00) | AAK1CYP3A4MKNK2ROCK2NR2C2 | |
| SCHEMBL20447184 | 0.86 | AAK1 (1.00) | AAK1CYP3A4MKNK2ROCK2NR2C2 | |
| SCHEMBL30061276 | 0.86 | AAK1 (1.00) | AAK1CYP3A4MKNK2ROCK2PRKG2 | |
| SCHEMBL17143659 | 0.86 | AAK1 (1.00) | AAK1CYP3A4MKNK2ROCK2PRKG2 | |
| SCHEMBL17143657 | 0.86 | AAK1 (1.00) | AAK1CYP3A4MKNK2ROCK2PRKG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115484951-A | AAK1 inhibitors for the treatment of viral infections | 莱西肯医药有限公司 | 2022-12-16 | — | — | CN | disclosed |
| US-10981910-B2 | Biaryl kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-04-20 | — | — | US | disclosed |
| CN-112142655-A | Biaryl kinase inhibitors | 百时美施贵宝公司 | 2020-12-29 | — | — | CN | disclosed |
| CN-108368084-B | Biaryl kinase inhibitors | 百时美施贵宝公司 | 2020-10-16 | — | — | CN | disclosed |
| US-20200317671-A1 | BIARYL KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2020-10-08 | — | — | US | disclosed |
| US-10351563-B2 | Biaryl kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-07-16 | — | — | US | disclosed |
| US-20190048006-A1 | BIARYL KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2019-02-14 | — | — | US | disclosed |
| US-9902722-B2 | Biaryl kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10981910-B2 | Biaryl kinase inhibitors | AAK1, NCK1, MARCKS | AAK1 1/4885CYP3A4 4488/4885MKNK2 45/4885 |
| US-20200317671-A1 | BIARYL KINASE INHIBITORS | AAK1, NCK1, MARCKS | AAK1 1/4885CYP3A4 4488/4885MKNK2 45/4885 |
| US-20190048006-A1 | BIARYL KINASE INHIBITORS | AAK1, NCK1, MARCKS | AAK1 1/4885CYP3A4 4488/4885MKNK2 45/4885 |
| US-10351563-B2 | Biaryl kinase inhibitors | AAK1, NCK1, MARCKS | AAK1 1/4885CYP3A4 4488/4885MKNK2 45/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.