Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.43 |
| ▸ | SIK1 | P57059 | 5/20 | 0.39 |
| ▸ | SIK2 | Q9H0K1 | 5/20 | 0.39 |
| ▸ | SIK3 | Q9Y2K2 | 5/20 | 0.39 |
| ▸ | WNT1 | P04628 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | CSF1R | P07333 | 5/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19902619 | 0.93 | SIK1 (0.47) | USP30ROCK1ROCK2SIK1SIK2 | |
| SCHEMBL19902587 | 0.93 | USP30 (0.57) | USP30ROCK1ROCK2SIK1SIK2 | |
| SCHEMBL19902560 | 0.91 | USP30 (0.44) | USP30ROCK1ROCK2SIK1SIK2 | |
| SCHEMBL19902563 | 0.91 | USP30 (0.45) | USP30ROCK1ROCK2SIK1SIK2 | |
| SCHEMBL19902584 | 0.91 | USP30 (0.45) | USP30ROCK1ROCK2SIK1SIK2 | |
| SCHEMBL19902588 | 0.91 | CSF1R (0.45) | USP30ROCK1ROCK2SIK1SIK2 | |
| SCHEMBL19902394 | 0.89 | SIK1 (0.42) | USP30ROCK1ROCK2SIK1SIK2 | |
| SCHEMBL19902368 | 0.88 | ROCK1 (0.49) | USP30ROCK1ROCK2CSF1RCCNA2 | |
| SCHEMBL19902518 | 0.86 | CSF1R (0.46) | USP30ROCK1ROCK2CSF1RCCNA2 | |
| SCHEMBL19902392 | 0.86 | ROCK1 (0.43) | USP30ROCK1ROCK2DYRK1ACSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9902702-B2 | Spirocycloheptanes as inhibitors of rock | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-02-27 | — | — | US | disclosed |