Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 6/20 | 0.40 |
| ▸ | AR | P10275 | 4/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | LATS1 | O95835 | 1/20 | 0.40 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.38 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | KDM4B | O94953 | 1/20 | 0.38 |
| ▸ | KDM5C | P41229 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12756150 | 0.85 | KDM4E (0.40) | PRMT5WDR77PARP1AURKAAURKB | |
| SCHEMBL19153584 | 0.79 | PRMT5 (0.44) | PRMT5WDR77PARP1ARCSNK2A1 | |
| SCHEMBL25945842 | 0.77 | LATS1 (0.42) | PARP1AURKALATS1LATS2KDM5A | |
| SCHEMBL20901592 | 0.77 | GRM4 (0.42) | PARP1LATS1LATS2 | |
| SCHEMBL19153845 | 0.75 | PARP1 (0.45) | PRMT5WDR77PARP1AURKAAURKB | |
| SCHEMBL30995048 | 0.75 | PARP1 (0.42) | PRMT5WDR77PARP1ARCSNK2A1 | |
| SCHEMBL29276201 | 0.75 | PARP1 (0.42) | PRMT5WDR77PARP1ARCSNK2A1 | |
| SCHEMBL28694341 | 0.75 | PARP1 (0.42) | PRMT5WDR77PARP1ARCSNK2A1 | |
| SCHEMBL18237348 | 0.75 | POLB (0.45) | PRMT5WDR77PARP1CSNK2A1KDM5A | |
| SCHEMBL29276157 | 0.73 | PARP1 (0.46) | PRMT5WDR77PARP1CSNK2A1KDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9902702-B2 | Spirocycloheptanes as inhibitors of rock | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-02-27 | — | — | US | disclosed |