Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 20/20 | 0.81 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19904305 | 0.93 | ABL1 (0.82) | ABL1KCNH2 | |
| SCHEMBL16864666 | 0.90 | ABL1 (1.00) | ABL1KCNH2 | |
| SCHEMBL19904323 | 0.87 | ABL1 (0.80) | ABL1KCNH2 | |
| SCHEMBL19904234 | 0.86 | ABL1 (0.81) | ABL1 | |
| SCHEMBL19904235 | 0.86 | ABL1 (0.81) | ABL1KCNH2 | |
| SCHEMBL19904272 | 0.85 | ABL1 (0.79) | ABL1KCNH2 | |
| SCHEMBL22725543 | 0.85 | ABL1 (0.67) | ABL1KCNH2 | |
| SCHEMBL22837852 | 0.84 | ABL1 (0.65) | ABL1KCNH2 | |
| SCHEMBL15393010 | 0.83 | ABL1 (1.00) | ABL1KCNH2 | |
| SCHEMBL21477612 | 0.83 | ABL1 (0.69) | ABL1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2858988-B1 | BENZAMIDE DERIVATIVES FOR INHIBITING THE ACTIVITY OF ABL1, ABL2 AND BCR-ABL1 | NOVARTIS AG (CH) | 2018-02-28 | — | — | EP | disclosed |