Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 19/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19904537 | 1.00 | ACACB (0.45) | ACACBNPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL19904377 | 0.91 | ACACB (0.40) | ACACBNPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL19904387 | 0.91 | ACACB (0.40) | ACACBNPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL29604785 | 0.86 | UGCG (0.48) | ACACB | |
| SCHEMBL19894457 | 0.86 | UGCG (0.48) | ACACB | |
| SCHEMBL29604275 | 0.86 | UGCG (0.48) | ACACB | |
| SCHEMBL16695486 | 0.86 | UGCG (0.48) | ACACB | |
| SCHEMBL16695549 | 0.86 | UGCG (0.48) | ACACB | |
| SCHEMBL19894459 | 0.86 | UGCG (0.48) | ACACB | |
| SCHEMBL29604649 | 0.86 | UGCG (0.48) | ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3063141-B1 | N-(1-HYDROXY-3-(PYRROLIDINYL)PROPAN-2-YL)PYRROLIDINE-3-CARBOXAMIDE DERIVATIVES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | BIOMARIN PHARM INC (US) | 2018-02-28 | — | — | EP | disclosed |