Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 20/20 | 0.89 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16860309 | 0.94 | ABL1 (1.00) | ABL1KCNH2 | |
| SCHEMBL16860444 | 0.94 | ABL1 (1.00) | ABL1KCNH2 | |
| SCHEMBL16860314 | 0.94 | ABL1 (1.00) | ABL1KCNH2 | |
| SCHEMBL16860470 | 0.93 | ABL1 (1.00) | ABL1KCNH2 | |
| SCHEMBL15393346 | 0.93 | ABL1 (1.00) | ABL1KCNH2 | |
| SCHEMBL17561803 | 0.92 | ABL1 (0.86) | ABL1KCNH2 | |
| SCHEMBL17561722 | 0.88 | ABL1 (0.87) | ABL1 | |
| SCHEMBL19904276 | 0.88 | ABL1 (0.80) | ABL1KCNH2 | |
| SCHEMBL16864678 | 0.88 | ABL1 (1.00) | ABL1KCNH2 | |
| SCHEMBL19894588 | 0.88 | ABL1 (1.00) | ABL1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2858988-B1 | BENZAMIDE DERIVATIVES FOR INHIBITING THE ACTIVITY OF ABL1, ABL2 AND BCR-ABL1 | NOVARTIS AG (CH) | 2018-02-28 | — | — | EP | disclosed |