Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 18/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16695518 | 0.84 | NOTUM (0.74) | NOTUM | |
| SCHEMBL16695109 | 0.84 | NOTUM (0.74) | NOTUM | |
| SCHEMBL16684657 | 0.83 | NOTUM (0.56) | NOTUMHSD11B1 | |
| SCHEMBL20840866 | 0.73 | NOTUM (0.68) | NOTUMHSD11B1 | |
| SCHEMBL16695469 | 0.72 | NOTUM (0.52) | NOTUM | |
| SCHEMBL16695224 | 0.70 | NOTUM (0.69) | NOTUM | |
| SCHEMBL16695200 | 0.70 | NOTUM (0.69) | NOTUM | |
| SCHEMBL16695079 | 0.69 | DPP4 (0.52) | NOTUM | |
| SCHEMBL16695072 | 0.69 | DPP4 (0.52) | NOTUM | |
| SCHEMBL29604898 | 0.69 | DPP4 (0.52) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3063141-B1 | N-(1-HYDROXY-3-(PYRROLIDINYL)PROPAN-2-YL)PYRROLIDINE-3-CARBOXAMIDE DERIVATIVES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | BIOMARIN PHARM INC (US) | 2018-02-28 | — | — | EP | disclosed |