Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | CCR1 | P32246 | 1/20 | 0.45 |
| ▸ | WDR91 | A4D1P6 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19904577 | 0.96 | NOTUM (0.46) | NOTUMHTR1ACCR1WDR91GAA | |
| SCHEMBL19904392 | 0.92 | ACACB (0.47) | NOTUMHTR1ACCR1 | |
| SCHEMBL19904620 | 0.90 | NOTUM (0.43) | NOTUMHTR1ACCR1WDR91GAA | |
| SCHEMBL19904475 | 0.88 | HPGD (0.43) | NOTUMHTR1ACCR1GAAMAPT | |
| SCHEMBL19904652 | 0.88 | KMT2A (0.49) | NOTUMHTR1ACCR1GAAMAPT | |
| SCHEMBL19904517 | 0.88 | HPGD (0.43) | NOTUMHTR1ACCR1GAAMAPT | |
| SCHEMBL18101715 | 0.88 | KMT2A (0.49) | NOTUMHTR1ACCR1GAAMAPT | |
| SCHEMBL18101714 | 0.88 | KMT2A (0.49) | NOTUMHTR1ACCR1GAAMAPT | |
| SCHEMBL18101713 | 0.88 | KMT2A (0.49) | NOTUMHTR1ACCR1GAAMAPT | |
| SCHEMBL19904451 | 0.88 | KMT2A (0.49) | NOTUMHTR1ACCR1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3063141-B1 | N-(1-HYDROXY-3-(PYRROLIDINYL)PROPAN-2-YL)PYRROLIDINE-3-CARBOXAMIDE DERIVATIVES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | BIOMARIN PHARM INC (US) | 2018-02-28 | — | — | EP | disclosed |