Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | PRMT1 | Q99873 | 9/20 | 0.32 |
| ▸ | CARM1 | Q86X55 | 6/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16129020 | 0.90 | S1PR1 (0.34) | ARS1PR1PRMT1CARM1 | |
| SCHEMBL16129018 | 0.89 | CARM1 (0.35) | ARS1PR1PRMT1CARM1 | |
| SCHEMBL16129012 | 0.87 | S1PR1 (0.39) | ARS1PR1PRMT1CARM1 | |
| SCHEMBL16129002 | 0.85 | CARM1 (0.35) | S1PR1PRMT1CARM1 | |
| SCHEMBL19432090 | 0.84 | S1PR1 (0.34) | ARS1PR1PRMT1CARM1 | |
| SCHEMBL19431995 | 0.84 | PRMT1 (0.32) | ARPRMT1CARM1 | |
| SCHEMBL16129006 | 0.83 | S1PR1 (0.39) | ARS1PR1PRMT1CARM1 | |
| SCHEMBL19432322 | 0.81 | SLC6A2 (0.32) | PRMT1CARM1 | |
| SCHEMBL16124050 | 0.80 | PRMT1 (0.38) | PRMT1CARM1 | |
| SCHEMBL16127635 | 0.80 | PRMT1 (0.33) | ARPRMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970134-B1 | PYRAZOLE DERIVATIVES AS PRMT1 INHIBITORS AND USES THEREOF | EPIZYME INC (US) | 2018-02-28 | — | — | EP | disclosed |