Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.52 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | KMO | O15229 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.42 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.39 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.37 |
| ▸ | POLQ | O75417 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15345147 | 0.79 | CYP11B1 (0.57) | CYP11B1CYP11B2NOTUMHDAC4KDM5B | |
| SCHEMBL15473162 | 0.77 | PIK3CA (0.45) | CYP11B1CYP11B2NOTUMKDM5BLCK | |
| SCHEMBL15341897 | 0.75 | CYP11B1 (0.53) | CYP11B1CYP11B2NOTUMHDAC4KDM5B | |
| SCHEMBL14320634 | 0.73 | CYP11B1 (0.64) | CYP11B1CYP11B2NOTUMHDAC4KDM5B | |
| SCHEMBL3582361 | 0.73 | CYP11B1 (0.51) | CYP11B1CYP11B2NOTUMHDAC4ALDH1A1 | |
| SCHEMBL10187283 | 0.72 | ADORA2A (0.57) | KMOASIC3LCKTNK2MET | |
| SCHEMBL15345191 | 0.69 | CCR1 (0.47) | CYP11B1CYP11B2NOTUMGRM5METAP2 | |
| SCHEMBL154510 | 0.68 | CYP11B1 (0.52) | CYP11B1CYP11B2NOTUMHDAC4PIK3CA | |
| SCHEMBL2334976 | 0.68 | CYP11B1 (0.52) | CYP11B1CYP11B2NOTUMHDAC4KDM5B | |
| SCHEMBL25094648 | 0.68 | CYP11B1 (0.53) | CYP11B1CYP11B2NOTUMHDAC4KDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057959-B1 | DNA-PK INHIBITORS | VERTEX PHARMA (US) | 2018-02-28 | — | — | EP | disclosed |